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Senior Scientist – Sample Preparation, Spatial/ Microscopy

Location: Pleasanton, California

At 10x Genomics, accelerating our understanding of biology is more than a mission for us. It’s a commitment. This is the century of biology, and the breakthroughs we make now have the potential to change the world.

We enable scientists to advance their research, allowing them to address scientific questions they didn’t even know they could ask. Our tools have enabled fundamental discoveries described in over 800 peer-reviewed publications across multiple application areas, including cancer, immunology, and neuroscience.

Our teams are empowered and encouraged to follow their passions, pursue new ideas, and perform at their best in an inclusive and dynamic environment. The innovations and discoveries that we enable together will lead to better technologies, better treatments, and a better future. Find out how you can make a 10x difference.

Scientist/ Senior Scientist, Sample Preparation, Spatial

We are looking for an exceptional scientist to drive new research and product development efforts in our Sample Preparation department. 

The ideal candidate will have a solid knowledge in histology (including tissue embedding), molecular biology, and microscopy. 

He/she should be driven by building innovative, robust and truly enabling products and enjoy working in a truly multi-disciplinary environment. The successful candidate in this position will interact closely with colleagues in computational biology, software, chemistry, and microfluidics.

Key Responsibilities:

Conceive and develop and novel tissue preparation strategies for downstream molecular biology applications, including but not limited to snap-frozen tissue, FFPE tissue, and hydrogel-embedded tissue.
Design and execute assays for analyzing the performance of tissue prep methods using molecular biology and microscopy techniques (e.g. immunofluorescence or in situ hybridization)
Plan and perform systematic workflow and protocol optimization, in close collaboration with synthetic chemistry, molecular biology and computational biology teams   
Contribute tissue biology and pathology expertise and leadership to cross-disciplinary product teams

Required Skills and Background:

PhD or MD/PhD with a minimum of 3 years post-graduate experience in academia and/or industry. Bioengineering, chemistry, biochemistry, pathology, molecular biology, or a related field.
Proven and deep knowledge in histology or novel tissue analysis methods, as evidenced by peer-reviewed publications, published patents, or commercialized products
Microscopy skills including multiplex antibody hybridization 
Familiarity with data analysis
Strong organizational skills
Strong written and oral communication skills
Strong troubleshooting and problem-solving skills
Ability to work in a fast-paced and quickly changing environment
Desire to build game-changing technologies and impact the world of life science research

Desired Skills and Background:

Experience with tissue arrays
Experience with next-generation sequencing



All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, sexual orientation, gender identity, national origin, protected veteran status, or on the basis of disability.




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Pleasanton, CA

10x Genomics
6230 Stoneridge Mall Road
Pleasanton, CA 94588-3260
+1 925 401 7300
+1 800 709 1208

San Francisco, CA

10x Genomics
Three Embarcadero Center,
Ste. 2330
San Francisco, CA 94111
+1 925 401 7300
+1 800 709 1208

Leiden, The Netherlands

10x Genomics B.V.
Crown Business Center Key Point II,
Schipholweg 103,
2316 XC Leiden,
The Netherlands

Stockholm, Sweden

Spatial Transcriptomics,
Part of 10x Genomics, Inc
Södra Fiskartorpsvägen 15C,
114 33 Stockholm,


10x Genomics Pte Ltd
Science Park 2,
20 Science Park Road,
#02-32A/33 Teletech Park,
Singapore 117674

Shanghai, China

10x Genomics (Shanghai) Co., Ltd
2421, Cloud 9 International Plaza,
No 1018 Changning Road,
Shanghai, 200042 China