Join Our Team

Sr. Mechanical Engineer

Location: Pleasanton, CA

10x Genomics is building tools for scientific discovery that reveal and address the true complexities of biology and disease. Through a combination of novel microfluidics, chemistry and bioinformatics, our award-winning Chromium™ System is enabling researchers around the world to more fully understand the fundamentals of biology at unprecedented resolution and scale. Learn more at


Fueled by equal parts scientific vision and determined passion, we are delivering unprecedented innovation to short-read sequencing technologies and transforming how genomic information is accessed. You will feel the 10x difference the moment you enter our offices and labs. There’s a dynamic energy here, and we’re looking for the best of the best to be a part of it. We are seeking talented professionals excited to build new technology that advances scientific research while growing their career within a dynamic, supportive environment.

Staff Mechanical Engineer

 10x Genomics is a rapidly growing company in the life sciences, whose core technology combines advances in instrumentation, chemistry, biochemistry, microfluidics and computational biology. 10x is looking for an outstanding individual to join its Instrumentation Engineering team supporting our ultra-precision mechanical designs and execution of 10x products.

 The ideal candidate will have a strong background in Mechanical Engineering of automation and life sciences instrumentation.  Demonstrated hands on experience with SolidWorks and PDM software is required.  Previous experience in producing mechanical designs that include automation, fluid handling and instrument structural components are a must.


Key Responsibilities


  • Lead responsible for the design, development, and release of mechanical designs for life science instrumentation or medical capital equipment.
  • Designing pneumatic systems for microfluidic management, including pressure control architecture and the selection of sensors, valves and pumps.
  • Developing instrument electro-mechanical and structural components
  • Coordinate designs with other key functions including Assay, Optical, Electrical and System Engineering.
  • Development of automated fluid and consumables handling automation/robotics.
  • Proven track record of taking new products from concept through design and into manufacturing.
  • Thorough understanding and hands-on experience producing mechanical design documentation, in support of releasing new products into manufacturing.
  • Experience with managing both internal and external (out-sourced) product development efforts.


Required Skills and Qualifications


  • Master’s degree in Mechanical Engineering with 10+ years of experience in life science instrumentation, and/or automation/robotics mechanical design.
  • Proficient in SolidWorks
  • Understanding of GD&T and statistical tolerance analysis
  • Understands basic thermal dynamics, fluid dynamics, and stress analysis.
  • Working knowledge and understanding of pneumatics is a strong plus
  • Familiarity with various ideation methodologies and design for manufacturing principles.
  • Experienced in Supplier Engagement and support, domestic and off-shore
  • Working knowledge of manufacturing techniques, machining, injection molding and consumables for biotech
  • Experience working with under ISO 9001
  • Desire to be part of a rapidly evolving organization, with a compelling technology, and taking products and processes to the next level.

All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, sexual orientation, gender identity, national origin, protected veteran status, or on the basis of disability.



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Pleasanton, CA

10x Genomics
6230 Stoneridge Mall Road
Pleasanton, CA 94588-3260
+1 925 401 7300
+1 800 709 1208

San Francisco, CA

10x Genomics
160 Spear St.,
Suite 1130
San Francisco, CA 94105
+1 925 401 7300
+1 800 709 1208

Leiden, The Netherlands

10x Genomics B.V.
Crown Business Center Key Point II,
Schipholweg 103,
2316 XC Leiden,
The Netherlands

Stockholm, Sweden

Spatial Transcriptomics,
Part of 10x Genomics, Inc
Södra Fiskartorpsvägen 15C,
114 33 Stockholm,


10x Genomics Pte Ltd
Science Park 2,
20 Science Park Road,
#02-32A/33 Teletech Park,
Singapore 117674

Shanghai, China

10x Genomics (Shanghai) Co., Ltd
2421, Cloud 9 International Plaza,
No 1018 Changning Road,
Shanghai, 200042 China