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Biocompare: Charting the map of neuronal fate specification using single cell transcriptomics and epigenomics
May 6 @ 9:00 am - 10:00 am PDT
Single cell transcriptomics allows researchers to disentangle orthogonal sources of transcriptional variation, which provides an unprecedented insight into cellular diversity in heterogeneous populations, such as human tissues. Single cell analysis is rapidly becoming a method of choice for identifying candidate regulators of cell identity, developmental processes, and disease responses. Tomasz Nowakowski’s lab is interested in identifying the molecular mechanisms that give rise to the diverse subtypes of neuronal cells in the human cerebral cortex. Toward this goal, they are generating comprehensive cellular-resolution reference datasets of molecular states in primary tissues. They have found that during development, transcriptomic and epigenomic features contribute complementary information about developmental processes. In particular, single cell epigenomic information identifies putative regulatory relationships that control developmental transition between neural stem cells and differentiated neurons. In his talk, he will describe how his lab applies these methods to understand developmental processes that give rise to the human cerebral cortex.