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GenomeWeb: Using Single-Cell Multiomics to Reveal New Insights into Uveal Melanoma Evolution and Therapeutic Resistance
May 19 @ 1:00 pm - 2:00 pm EDT
Uveal melanoma (UM) is a highly metastatic cancer that, in contrast to cutaneous melanoma, is largely unresponsive to checkpoint immunotherapy. Despite a well characterized genomic landscape and prognostically distinct molecular subtypes, a complete understanding of UM progression, metastasis and therapeutic resistance remains elusive.
Join Dr. J. William Harbour, Professor and Associate Director for Basic Science at Sylvester Comprehensive Cancer Center of the University of Miami, for a webinar to learn more about his recently published research studying the evolution of UM tumors and their microenvironments. Using single cell approaches from 10x Genomics for gene expression, genomic copy number variation (CNV) and T and B cell receptor typing, Dr. Harbour and team comprehensively characterized 8 primary tumors and 3 metastatic tumors revealing new insights into UM biology and identifying a new putative checkpoint inhibitor target, LAG3.