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Single-Cell and Spatial Transcriptomic Profiling of the Septic Kidney

August 13 @ 10:00 am - 11:00 am PDT

This webinar will discuss a study that combined single-cell gene expression and spatial gene expression to understand the evolution of sepsis in the kidney at the cellular and molecular level. Understanding the pathophysiology of acute kidney injury is crucial for the comprehensive treatment of sepsis and its complications, but the exact cellular and molecular contributors to this multifaceted response remain unknown. Furthermore, the kidney is a highly complex organ, in which epithelial, endothelial, immune, and stromal cells are at constant interplay. In this webinar, Dr. Takashi Hato of Indiana University will describe a project that used both Chromium single-cell gene expression and Visium spatial gene expression solutions to provide a detailed and precise view of the evolution of sepsis in the kidney, as well as identify potential SARS-CoV-2 entry points.