Exome Solution

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The Chromium Exome Solution

Reach Beyond the Standard Exome

The Chromium Exome provides long range information, enabling phasing, structural variant detection
and copy number determination. Low complexity and repetitive regions previously missed
with short-read sequencing are now accessible.

Our Solution Features

  • High-quality libraries from only 1 ng of genomic DNA
  • Detect large scale structural variants (SVs) including gene fusions
  • Call and phase variants across the entire exome
  • Detect variants in genes inaccessible to standard short-read libraries
  • Useful for high sequence homology, including problematic duplications, inversions and pseudogenes
  • Optimized baits utilize Linked-Reads for intron-spanning
View the Workflow Watch it Work

The Chromium Controller

Compact, sleek, efficient.

The compact, sleek Chromium Controller has been designed to rapidly and efficiently automate the equivalent of 100,000s to 1,000,000s of pipetting steps for highly parallel sample partitioning and molecular barcoding. The Chromium Controller allows a user to run any of our Chromium Single Cell 3′, V(D)J, Genome and Exome Solutions. A dedicated Chromium Single Cell Controller is also available for users that exclusively run our Chromium Single Cell 3′ and V(D)J Solutions.

View Our Controller Gallery


Chromium Genome v2 Library Kit
& Gel Bead Kit

The Chromium Controller now supports our new Chromium Genome Reagent Kits with v2 chemistry, with the following refinements:

  • Chromium Genome Library Kit & Gel Bead Kit v2 comes in 16 and 96-reaction (HT) configurations, offering a flexible workflow that can be scaled based on the needs of each user
  • The Chromium Genome HT Library Kit & Gel Bead Kit v2 can be automated on industry standard liquid handlers and has a significant cost advantage per sample


  • Chromium Genome HT Library Kit & Gel Bead Kit v2, 96-reactions
  • Chromium Genome Library Kit & Gel Bead Kit v2, 16-reactions
  • Chromium Genome Chip Kit v2, 48-reactions

Purchase Separately:

  • Chromium i7 Multiplex Kit, 96-reactions
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HMW DNA sample preparation techniques and best practices

Jill Herschleb, PhD
10x Genomics
November 28, 2017
Pleasanton, CA

Structural variant and haplotype analysis with Linked-Read data

Sarah Garcia, PhD & David Stafford
10x Genomics
November 28, 2017
Pleasanton, CA

Genome-wide reconstruction of complex structural variants

Noah Spies
Stanford University
March 21, 2017
User Group Meeting - San Francisco, CA

Addressing difficult biology: 10x and OneSeq phased exome

David Craig
Translational Genomics Research Institute
February 13, 2017
AGBT Annual Meeting - Hollywood, FL

Universal approach for noninvasive prenatal testing of single gene diseases

Winnie Hui
The Chinese University of Hong Kong
February 13, 2017
AGBT Annual Meeting - Hollywood, FL

Deciphering complex structural variation using Linked-Reads

Jill Herschleb
10x Genomics, Inc.
January 14, 2017
Plant & Animal Genome - San Diego, CA

Linked-Reads for improved genomics

Sarah Garcia
10x Genomics, Inc.
November 10, 2016
AMP Annual Meeting - Charlotte, NC

Exploring 50 whole genomes with Chromium Linked-Reads

Chris Whelan
Broad Institute
October 21, 2016
ASHG Annual Meeting - Vancouver, BC

Resolving short reads and distinguishing variants in PMS2

Charlly Kao
Children's Hospital of Philadelphia
October 20, 2016
ASHG Annual Meeting - Vancouver, BC

Improving genome analysis with Linked-Reads

Deanna Church
10x Genomics, Inc.
August 15, 2016
Pleasanton, CA

Resolving the “dark matter” of the exome

Hakon Hakonarson
Children’s Hospital of Philadelphia
June 02, 2016
Nature Webcast

Moving into the darkness: Improving variant analysis with Linked-Reads

  • ASHG 2017
    Orlando, FL
    October 17 - October 21, 2017

Linked-Read sequencing for molecular cytogenetics

  • ASHG 2017
    Orlando, FL
    October 17 - October 21, 2017

Long range applications with short read sequencing

  • American Society of Human Genetics (ASHG) Annual Meeting
    Vancouver, BC
    October 18 - 22, 2016
  • Advances in Genome Biology and Technology (AGBT) Precision Health Meeting
    Scottsdale, AZ
    September 22 - 24, 2016

Alignment and variant calling in segmental duplications with linked-read data

  • Wellcome Trust Genome Informatics Conference
    Cambridge, UK
    September 19 - 22, 2016

Enabling more complete genome analysis using 10x Linked-Reads

  • Cancer Genomics Consortium (CGC) Summer Meeting
    Denver, CO
    August 8 - 10, 2016

Linked-Reads enable detailed, phased resolution of structural variation in the cancer genome

  • American Association for Cancer Research (AACR) Annual Meeting
    New Orleans, LA
    April 16 - 20, 2016

Enhancing 10x Genomics’ GemCode Technology platform through optimization of QIAGEN’s HMW sample prep solutions

  • Advances in Genome Biology and Technology (AGBT) General Meeting
    Orlando, FL
    February 10 - 13, 2016

Order your Chromium Controller, today.

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