Can I decipher the mechanisms involved in the antigen-specific immune response?

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Map the Adaptive Immune Response
at Single Cell Resolution

Adaptive immunity is critical for defending the body against disease and infection. The adaptive immune response requires the ability to respond to different types of antigens, activate pathways that eliminate specific pathogens, and develop immunological memory so that subsequent infections or disease can be quickly identified and removed. This complex process is mediated through the specific recognition of antigens by lymphocytes, and the dynamics of the immune response are fueled by the genetic diversity of lymphocyte receptors.

Single cell sequencing solutions from 10x Genomics provide new research avenues for immunologists to map the immune repertoire with high resolution.

  • On a cell-by-cell basis, characterize hundreds to tens of thousands of lymphocytes, their immune repertoires, and antigen specificity, all in the same assay
  • Study dynamic interactions between lymphocytes and target antigens and discover new targets
  • Better understand mechanisms that contribute to lymphocyte differentiation and memory development
  • Identify cell-type-specific differences in the chromatin landscape of the immune response
  • Accelerate immunotherapy development with 10x Genomics’ comprehensive and scalable solutions

Get a Multidimensional View of Adaptive Immunity and Beyond with New Single Cell Solutions from 10x Genomics

Single Cell Immune Profiling
Simultaneously measure cell types, antigens, and their paired TCR sequences
Single Cell Immune Profiling Solution with Antigen Specificity

The adaptive immune response is mediated by major histocompatibility complex (MHC) cell surface proteins presenting antigens to T cells. These events trigger multiple downstream activities that launch the immune response. A detailed molecular profile of the paired T-cell receptors (TCRs), combined with their target antigens and cellular transcriptomes, will allow you to accurately characterize these complex events. Our Single Cell Immune Profiling Solution with Feature Barcoding technology for antigen specificity allows you to:

  • Simultaneously measure antigens, their cognate-specific paired TCRs, and transcriptomes on a cell-by-cell basis
  • Study dynamic interactions between lymphocytes and target cells
  • Screen antigens with high specificity and sensitivity using multiplexing
  • Discover new target antigens
  • Map immune cell responses to specific pathogens to enhance CAR-T or TCR cell therapies
Single Cell Immune Profiling
Integrate measurements of cell surface proteins, transcriptomes, and the immune repertoire
Single Cell Immune Profiling Solution with Cell Surface Protein

Characterizing the phenotype and distribution of different immune cell subsets and their contributions to immunological disease requires a precise and detailed understanding of immune cell diversity. Mapping immune signatures will enable you to tease apart how these cells are altered in disease or development. Our Single Cell Immune Profiling Solution using Feature Barcoding technology for Cell Surface Protein allows you to:

  • Integrate measurements of cell surface proteins, an unbiased transcriptome, and the immune repertoire into a single readout
  • Further increase phenotypic specificity by identifying protein isoforms
  • Characterize the tumor microenvironment and tumor-infiltrating lymphocytes at single cell resolution
  • Accelerate immunotherapy development
  • Simultaneously assay cellular and molecular phenotypes of the immune system in any tissue
Single Cell Gene Expression
Simultaneously characterize adaptive immune repertoires and gene expression
Single Cell Immune Profiling Solution

The specificity of adaptive immunity relies on a vast repertoire of T- and B-lymphocyte receptors generated through the somatic recombination of multiple possible gene segments, which results in unique antigen receptor expression on a cell-by-cell basis. Single cell immune profiling enables paired full-length receptor sequencing for unbiased clonotype analysis of T- and B-cell populations in individual cells. With our Single Cell Immune Profiling Solution, you can:

  • Characterize adaptive immune repertoires alongside cellular gene expression in hundreds to tens of thousands of single cells
  • Uncover the clonality, diversity, and cellular context of the immune repertoire
  • Unravel the nature and clonality of the adaptive immune response
Single Cell Gene Expression
Uncover the epigenetic basis of immunity and autoimmune disorders
Single Cell ATAC Solution

Epigenetic regulation has been implicated in autoimmune disorders, allergic disease, and inflammation. However, the underlying causes and disease mechanisms are not yet widely understood. Dissecting the epigenetic mechanisms of the immune response will allow a better understanding of immune cell differentiation, subset specification, and memory development. Our Single Cell ATAC Solution enables you to:

  • Identify cell-type-specific differences in the chromatin landscape of the immune response in hundreds to tens of thousands of single cells
  • Understand the impact of epigenetic modifications on immunity, including immune cell differentiation, T-cell activation, and antigen receptor specificity
  • Reveal the epigenetic basis of autoimmune and inflammatory disorders
Get a Multidimensional View of Complex Cellular Systems with New Single Cell Solutions from 10x Genomics
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Order your 10x system, today.