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Protein Engineer – NGS Applications

Location: Pleasanton, CA

Protein Engineer – NGS Applications

Location: Pleasanton, CA

10x Genomics is building tools for scientific discovery that reveal and address the true complexities of biology and disease. Through a combination of novel microfluidics, chemistry and bioinformatics, our award-winning Chromium™ System is enabling researchers around the world to more fully understand the fundamentals of biology at unprecedented resolution and scale. Learn more at 10xGenomics.com.

 #GOEXPONENTIAL

 Fueled by equal parts scientific vision and determined passion, we are delivering unprecedented innovation to short-read sequencing technologies and transforming how genomic information is accessed. You will feel the 10x difference the moment you enter our offices and labs. There’s a dynamic energy here, and we’re looking for the best of the best to be a part of it. We are seeking talented professionals excited to build new technology that advances scientific research while growing their career within a dynamic, supportive environment.

 

PROTEIN ENGINEER

We are looking for an exceptional scientist to drive protein engineering and related reagent development efforts in our Molecular Biology department. The ideal candidate will have a proven track-record of developing novel enzyme variants and other protein reagents for use in complex molecular biology applications. He/she should be driven by making great products and enjoy working in a truly multi-disciplinary environment. This position will interact closely with colleagues in computational biology, chemistry, consumables process development, manufacturing and microfluidics. 

 

Key Responsibilities

  • Conceive, identify and develop novel/optimized enzymes and other protein reagents for assays running on the 10x Genomics technology platform
  • Plan and perform protein development by screening or directed evolution
  • Plan and perform protein optimization by modeling, identification of limiting steps and use of formal design of experiment (DOE) approaches
  • Plan and perform protein expression, purification and characterization
  • Contribute protein engineering expertise and leadership to cross-disciplinary product development teams
  • Work closely with computational biologists to interpret data generated by novel/optimized protein reagents
  • Work closely with process development and manufacturing staff to develop quality control and manufacturing strategies for novel/optimized reagents

Required Skills and Background

  • PhD in biochemistry, molecular biology or a similar field, with a minimum of 3 years post-graduate experience in academia and/or industry
  • Proven ability to develop novel optimized enzymes and affinity reagents preferably with direct experience creating DNA and RNA modification enzymes, as evidenced by peer-reviewed publications, published patents or launched products
  • Experience in enzyme assay design and development as well as activity screening and directed evolution and or enzyme screening
  • Experience in design, construction and characterization of protein variant libraries
  • Experience in protein expression, purification and characterization
  • Strong organizational skills
  • Strong written and oral communication skills
  • Ability to work in a fast-paced and quickly changing environment
  • A strong desire to build game-changing technologies and impact the world of life science research

    #LI-TJ1

 

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カリフォルニア州、プレザントン

10x Genomics
7068 Koll Center Parkway,
Suite 401
Pleasanton, CA 94566
+1 925 401 7300
+1 800 709 1208

カリフォルニア州、サンフランシスコ

10x Genomics
160 Spear St.,
Suite 1130
San Francisco, CA 94105
+1 925 401 7300
+1 800 709 1208

オランダ、ライデン

10x Genomics B.V.
Crown Business Center Key Point II,
Schipholweg 103,
2316 XC Leiden,
The Netherlands
+31 (20) 888 6622

スウェーデン、ストックホルム

Spatial Transcriptomics,
Part of 10x Genomics, Inc
Södra Fiskartorpsvägen 15C,
114 33 Stockholm,
Sweden

シンガポール

10x Genomics Pte Ltd
Science Park 2,
20 Science Park Road,
#02-32A/33 Teletech Park,
Singapore 117674

中国、上海

10x Genomics (Shanghai) Co., Ltd
2421, Cloud 9 International Plaza,
No 1018 Changning Road,
Shanghai, 200042 China