Research Associate 2-Molecular Biology/Product Development
Location: Pleasanton CA
At 10x Genomics, accelerating our understanding of biology is more than a mission for us. It’s a commitment. This is the century of biology, and the breakthroughs we make now have the potential to change the world.
We enable scientists to advance their research, allowing them to address scientific questions they didn’t even know they could ask. Our tools have enabled fundamental discoveries described in over 800 peer-reviewed publications across multiple application areas, including cancer, immunology, and neuroscience.
Our teams are empowered and encouraged to follow their passions, pursue new ideas, and perform at their best in an inclusive and dynamic environment. The innovations and discoveries that we enable together will lead to better technologies, better treatments, and a better future. Find out how you can make a 10x difference.
About the role:
We are seeking an outstanding Research Associate to join the Product Development group to support the development and commercial launch of new products. This is a unique cross-disciplinary position that will work closely with a variety of groups including Molecular Biology, Chemistry, Microfluidics, QC, and Manufacturing, to develop and validate novel reagents for the rapid expansion of 10x product lines. Candidates must have a broad working knowledge of molecular biology and be able to apply that knowledge creatively and independently in a fast-paced work environment. The successful applicant will have exceptional attention to detail and the ability to meticulously execute and analyze highly complex experiments. Previous industry experience is essential.
Individuals applying for this position must be self-starters, strategic thinkers, action driven, flexible in changing direction and methods, thrive in a fast-paced environment, excel at managing multiple priorities, succeed in communicating with all levels within the organization and provide immediate contribution.
What you will be doing:
- Preparation, formulation, and testing of newly designed 10x reagents either from SOPs or R&D protocols.
- Create NGS libraries from single cells, tissues, or isolated DNA/RNA using 10x instruments and consumables.
- Conceive, develop, and implement new QC methods to assess reagent quality through a variety of analytical and functional tests.
- Perform reagent guard banding and stability studies.
- Maintenance of batch records, documentation and presentation of results, writing SOPs, and training other lab personnel.
- Assist in early stage product R&D
- Assist Production and other R&D teams with troubleshooting
To be successful, you will need:
- S. or M.S. in molecular biology, biochemistry, genetics, microbiology, analytical chemistry, or related field.
- 3+ (B.S.) or 1+ (M.S.) years of relevant biotechnology or pharmaceutical industry experience.
- Experience with a broad variety of molecular biology and analytical techniques including qPCR, RT-qPCR, ddPCR, FISH, flow cytometry, HPLC, PAGE, molecular cloning, gene editing, primer design, and nucleic acid isolation and manipulation.
- Proven ability to use a variety of scientific equipment including microscopes, plate readers, rheometers, Bioanalyzers, gel imagers, real-time PCR instruments, HPLC instruments, flow cytometers etc.
- Significant experience troubleshooting molecular biology-based assays.
- Proven ability to write SOPs and train others to successfully perform the work.
- Strong collaboration and communication skills.
- Ability to work independently
- Desire to work in a flexible and fast-paced startup environment.
Nice to have skills & background:
- Previous work with a variety of NGS sample preparation workflows and analysis.
- Past work in a process or product development role, especially technology transfer to manufacturing and/or QC groups.
- Experience operating liquid handling robots or other lab automation for high-throughput assays.
- Experience with cell culture and the handling of mammalian primary cells, cell lines, and tissues.
- Experience with microscopy and imaging systems
- Experience working with new and untested reagents.
- Experience creating and optimizing novel assays.
All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, sexual orientation, gender identity, national origin, protected veteran status, or on the basis of disability.