Cancer Research

High Resolution
Oncology Discovery

Expand cancer insights at the genome-wide and single cell level using 10x Genomics’ Chromium Solutions.

Our product offerings support multiple cancer research areas—from single nucleotide and structural variant detection to single cell whole transcriptome gene expression analysis of thousands of individual cells, including paired, full-length T- and B-cell immune repertoire profiling. Our cancer solutions will allow you to answer questions that you have never before thought possible.


10x Advantages in Cancer Research

Cancer Research
1
Unmask Tumor Heterogeneity

The inherent heterogeneity of cancer cell populations, including the diversity of normal, malignant, immune, and other cellular gene expression profiles of common and rare cell types, can be uncovered and analyzed at an astounding resolution.

2
Map the Immune Response

Elucidate tumor infiltrating lymphocyte phenotypes and clonal antigen recognition within the tissue microenvironment, and research molecular and cellular responses to novel immunotherapies derived from single cell genomics’ discoveries.

3
Better Characterization of Mutations in Cancer Susceptibility Genes

Accurately detect and resolve ambiguous variants, while maintaining haplotype information.

Cancer Research
4
Consolidate Multiple Assays into One Low-input Assay

Get a more accurate view of the cancer genomic landscape by detecting SNVs, CNVs, as well as balanced and complex structural variants in a single, comprehensive assay that requires only 1 ng of DNA input.

5
Complete Solutions, from Sample Prep to Analysis

A simplified workflow, along with cutting-edge and intuitive software, gives you the tools to effortlessly and rapidly complete your investigations.

Publications

Linked-Read sequencing resolves complex structural variants

Garcia S et al. 2017 Dec 8; Pre-print*.

Haplotypes drop by drop

Kitzman JO. Nat Biotechnol. 2016 Mar;34(3):296-8. doi: 10.1038/nbt.3500. PMID: 26963554.

Scientific Seminars

Genome-wide reconstruction of complex structural variants

 
March 21, 2017
User Group Meeting – San Francisco, CA

Harnessing the therapeutic potential of adoptively transferred cells

 
Aude Chapuis
Fred Hutchinson Cancer Research Center
June 22, 2017
Nature Webcast

Chromium single cell solutions

 
October 21, 2016
ASHG Annual Meeting – Vancouver, BC

Perturb-seq: High Throughput CRISPR Screening via Single-Cell RNA Sequencing

 
Dr. Jonathan Weissman
University of California, San Francisco and Howard Hughes Medical Institute
May 10, 2017
Nature Webinar

Resolving the “dark matter” of the exome

 
Hakon Hakonarson
Children’s Hospital of Philadelphia
June 03, 2016
Nature Webcast

Blog Posts

Datasets