Genetic Health

Decipher Disease
Mechanisms and Heritability
of Genetic Disorders

Have an exponential impact on genetic health by deciphering underlying genomic heterogeneity and heritability with our Chromium Solutions.

To truly understand disease mechanisms, heritability, and the development of therapies, we need access to more genomic information. Our Chromium Genome and Exome solutions use the power of Linked-Reads to construct long-range information from short-reads and provide access to more variants than any
other solution on the market today.


10x Advantages in Genetic Health

Genetic Health
1
Reliably Interrogate Unmappable Regions

Analyze more of the genome by accessing medically relevant regions that are unmappable with only short-reads, such as those located in NGS dead zones, for a more complete understanding of human health and disease.

2
Resolve Haplotypes for an Improved Understanding of Disease Inheritance

Identify changes that occur on maternal or paternal haplotypes and confidently call variants in cis or trans to better decipher the mechanisms underlying inherited disorders.

Genetic Health
3
Consolidate Multiple Assays into one Low-input Assay

Get access to more variants by detecting SNVs and CNVs, as well as balanced and complex structural variants, in a single, comprehensive assay that requires only 1 ng of DNA input.

4
Complete Solutions, from Sample Prep to Analysis

A simplified and fully automatable workflow, along with cutting-edge and intuitive software, gives you the tools to effortlessly and rapidly find answers to your complex biological questions.

Publications

Linked-Read sequencing resolves complex structural variants

Garcia S et al. 2017 Dec 8; Pre-print*.

Haplotypes drop by drop

Kitzman JO. Nat Biotechnol. 2016 Mar;34(3):296-8. doi: 10.1038/nbt.3500. PMID: 26963554.

Scientific Seminars

Resolving short reads and distinguishing variants in PMS2

 
October 21, 2016
ASHG Annual Meeting – Vancouver, BC

Addressing difficult biology: 10x and OneSeq phased exome

 
February 13, 2017
AGBT Annual Meeting – Hollywood, FL

Perturb-seq: High Throughput CRISPR Screening via Single-Cell RNA Sequencing

 
Dr. Jonathan Weissman
University of California, San Francisco and Howard Hughes Medical Institute
May 10, 2017
Nature Webinar

Genome-wide reconstruction of complex structural variants

 
March 21, 2017
User Group Meeting – San Francisco, CA

Deciphering complex structural variation using Linked-Reads

 
January 14, 2017
Plant & Animal Genome – San Diego, CA

Linked-Reads for improved genomics

 
November 11, 2016
AMP Annual Meeting – Charlotte, NC

Exploring 50 whole genomes with Chromium Linked-Reads

 
October 21, 2016
ASHG Annual Meeting – Vancouver, BC

Improving genome analysis with Linked-Reads

 
Deanna Church
10x Genomics, Inc.
August 15, 2016
Pleasanton, CA

Resolving the “dark matter” of the exome

 
Hakon Hakonarson
Children’s Hospital of Philadelphia
June 03, 2016
Nature Webcast

Blog Posts