Can I transform my understanding of genomics, transcriptomics, and epigenomics at single cell resolution?

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Reveal the Dynamics of Cellular Diversity
with Single Cell Sequencing

Multicellular organisms and dynamic biological processes consist of a complex interplay of multiple individual cells. Until recently, most molecular studies have relied on bulk analysis, combining all cells into a single average readout. Single cell sequencing technologies provide a high resolution view, helping you understand the molecular mechanisms of development and disease at the level of individual cells.

Characterize hundreds to tens of thousands of single cells, without the need for pre-selected cell types or markers, using 10x Genomics comprehensive and scalable single cell solutions.

  • Characterize intracellular heterogeneity, cell types and states, dynamic cellular transitions, and cell-to-cell interactions in hundreds to tens of thousands of cells
  • Reveal copy number variation, analyze the transcriptome, map the epigenetic landscape, and dissect adaptive immunity
  • Get a more comprehensive molecular readout by co-measuring gene expression with cell surface proteins and antigen specificity
  • Identify precise CRISPR-perturbations and associated molecular phenotypes in the same cell

Learn About Our Solutions for Different Research Areas

Get a Multidimensional View of Complex Cellular Systems with New Single Cell Solutions from 10x Genomics

Single Cell Gene Expression
Uncover the full spectrum of cellular diversity
on a cell-by-cell basis
Single Cell Gene Expression Solution

During development, differentiation, or disease, cells undergo dynamic molecular changes to generate diverse populations. 10x Genomics’ Chromium Single Cell Gene Expression Solution provides an unparalleled approach for characterizing complex samples at single cell resolution. Our latest reagent improvements vastly increase sensitivity, so you can detect even more unique transcripts per cell. With our solution, you can:

  • Discover biomarkers for distinct cell populations
  • Identify novel and rare cell types based on unbiased gene expression profiling
  • Uncover different cell states and cell subpopulations
  • Analyze and understand cellular heterogeneity and how it contributes to your biological system
  • Dissect the mechanisms of cellular development
  • Measure responses to therapies
Single Cell Gene Expression
Dissect genetic pathways that drive disease
Single Cell Gene Expression Solution
with CRISPR Screening

Pooled CRISPR screening is a powerful method for identifying genes involved in complex biological mechanisms such as cell proliferation, cell survival, and drug or toxin resistance. In order to dissect the molecular pathways that underlie key biological processes, you need the ability to identify precise CRISPR perturbations—and associated molecular phenotypes—on a cell-by-cell basis. Leverage our Feature Barcoding technology to directly capture and sequence barcoded guide RNAs. With our solution, you can:

  • Simultaneously identify CRISPR/Cas9 perturbations and their effects on gene expression from the same cell using barcoded guide RNAs
  • Implement high-throughput CRISPR-based genetic screens in hundreds to tens of thousands of cells
  • Analyze gene regulatory networks and signaling pathways involved in development and disease
Single Cell Immune Profiling
Track the expression of cell surface markers,
together with transcriptome measurements
Single Cell Gene Expression Solution
with Cell Surface Protein

During development, differentiation, and disease processes, cells undergo dynamic changes in cell type or state, leading to changes in the array of proteins and protein isoforms present on the cell surface. A multitude of cell surface marker proteins have been identified that distinguish cell types and cell states during normal development and in disease. Leverage our Feature Barcoding technology to label cells with DNA-barcoded antibodies against cell surface proteins in your single cell sequencing experiments. With our solution, you can:

  • Integrate measurements of cell surface proteins and unbiased transcriptomes into a single readout
  • Investigate cellular phenotypes in hundreds to tens of thousands of cells
  • Resolve cell populations by protein isoform expression
  • Identify novel cell types, biomarkers, or treatment targets
  • Dissect cell signaling pathways
Single Cell Immune Profiling
Study dynamic interactions between
lymphocytes and target antigens
Single Cell Immune Profiling Solution
with Antigen Specificity

Major histocompatibility complex (MHC) cell surface proteins present antigens to T cells, launching the adaptive immune response. In research, MHC multimers can be used as a tool to identify the antigen binding specificity of T cells. Our Feature Barcoding technology uses DNA barcodes to label MHC multimers, making it possible to measure antigen specificity with single cell sequencing. With our solution, you can:

  • Get a simultaneous readout of transcriptomes, paired T-cell receptor sequences, and target antigens on a cell-by-cell basis
  • Study dynamic interactions between lymphocytes and antigens
  • Link full-length, paired TCR α and β chain sequences with TCR-pMHC specificity
  • Map immune cell responses to specific pathogens to enhance CAR-T or TCR cell therapies
Single Cell Immune Profiling
Unravel multiple dimensions of immune cell function
Single Cell Immune Profiling Solution
with Cell Surface Protein

Characterizing the phenotype and distribution of different immune cell subsets and their contributions to disease requires a thorough understanding of immune cell diversity. Mapping immune signatures will enable you to tease apart how these cells are altered in disease or development. Leverage our Feature Barcoding technology to label cells with DNA-barcoded antibodies against cell surface proteins in your single cell sequencing experiments. With our solution, you can:

  • Integrate measurements of cell surface proteins, transcriptomes, and the immune repertoire into a single readout
  • Identify previously hard to distinguish protein isoforms and increase phenotypic specificity
  • Characterize the tumor microenvironment and tumor-infiltrating lymphocytes at single cell resolution to aid in immunotherapy development
  • Profile the diversity and phenotypes of immune cell types across diverse tissues and disease states, and monitor responses to therapeutic interventions
Single Cell Immune Profiling
Decipher the epigenetic basis of disease and development at single cell resolution
Single Cell ATAC Solution

Chromatin structure varies from cell to cell, and epigenetic variability is one of the key mechanisms for generating cell-specific DNA patterning and gene expression. Unlike genetic mutations, epigenetic alterations are dynamic and potentially reversible. With our solution, you can:

  • Profile the open chromatin landscape of tens of thousands of individual nuclei
  • Identify cell type differences in epigenetic regulation in rare cell populations
  • Investigate regulatory mechanisms governing cellular processes
  • Explore epigenetic dynamics in development or disease
Single Cell Immune Profiling
Unmask genetic heterogeneity and
map clonal evolution
Single Cell CNV Solution

Characterizing cell-to-cell genomic heterogeneity is important for understanding complex, heterogeneous diseases, including cancer and several neurological disorders. Traditional bulk copy number profiling methods only provide an average ploidy measurement, masking the true genetic diversity in your sample. With our solution, you can:

  • Detect copy number variation in hundreds to thousands of individual cells
  • Reveal the full spectrum of cellular genomes present in your sample
  • Map clonal evolution and identify rare clones
  • Investigate disease pathogenesis at the single cell level
Single Cell Immune Profiling
Simultaneously examine adaptive immune repertoires and cellular gene expression
Single Cell Immune Profiling Solution

The specificity of adaptive immunity relies on the vast repertoire of lymphocyte receptors generated through the recombination of gene segments. Single cell immune profiling enables paired full-length receptor sequencing for unbiased clonotype analysis of lymphocyte populations on a cell-by-cell basis. With our solution, you can:

  • Characterize adaptive immune repertoires alongside cellular gene expression in hundreds to tens of thousands of single cells
  • Perform paired full-length receptor sequencing for unbiased clonotype analysis of lymphocyte populations
  • Accelerate insights into the nature and clonality of the adaptive immune response
Get a Multidimensional View of Complex Cellular Systems with New Single Cell Solutions from 10x Genomics
Contact Me Request Pricing

Order your 10x system, today.