Drug Discovery and Development

Actionable insights for every stage of the pipeline

Success starts with the right resolution

Promising treatments for complex diseases are often thwarted by biological heterogeneity that leads to differences in disease manifestations and treatment responses, resulting in varied drug efficacy and toxicity. Single cell assays provide high-resolution multiomic readouts that empower researchers to dissect disease mechanisms and drug activity in greater detail than ever before. Learn how 10x Genomics single cell technologies can increase success and decrease risk by guiding target identification, characterization of mechanisms of action, biomarker discovery for patient stratification, and toxicity evaluation.

Across therapeutic areas...

  • Illustration of an infiltrating immune cell attacking a cancer cell

    Oncology & Immuno-oncology

    Elucidate complex and clinically relevant mechanisms that enable immune evasion. Identify molecular mediators of cancer resistance for novel therapeutic targets.
  • Illustration of various infectious agents, including bacteria and viruses

    Immunology & Infectious Disease

    Characterize immune cell states and infiltration associated with disease or infection. Link host immune response to a pathogen, infection recovery, or infection severity.
  • Illustrated sillhouette of a human head and brain filled with red and blue cells

    Neuroscience

    Build a complete picture of the complex biology of neurodegenerative diseases in multiple dimensions. Characterize disease-associated cellular phenotypes and uncover novel pathogenic effects.

A range of modalities...

  • Illustration of an arm hooked up to an IV for cell therapy with an inset of cells inside the IV bag

    Cell & Gene Therapy

    Characterize and optimize manufactured cell therapy products. Identify gene signatures to explain dose-limiting toxicities and resistance mechanisms.
  • Illustration of, from left to right, a syringe, a human body, and immune cells

    Antibody Discovery

    Identify potent neutralizing antibodies from infected or convalescent patient samples. Map antigens recognized by specific B-cell receptors, at scale.
  • Illustration of a syringe surrounded by various infectious agents

    Vaccine Development

    Examine the molecular mechanisms behind vaccine-elicited cell-mediated immunity. Characterize innate immune response with rich multiomic readouts.

For every stage of the pipeline...

  • Illustration of a magnifying glass examing immune cells

    Target Identification

    Accelerate hit identification and lead optimization. Identify and sustain a pipeline of novel targets with high-throughput screens at single cell resolution, giving your results more statistical power.
  • Illustration of a clipboard and checklist with items checked off

    Target Validation

    Advance promising targets through development by identifying treatment-responsive subpopulations. Decipher molecular mechanisms of action that govern therapeutic response and resistance.
  • Illustration featuring, from left to right, a solution in a test tube, a DNA strand, and a group of icons representing humans

    Translational and Clinical Research

    Stratify disease populations more effectively with detailed multiomic readouts that can separate responders from non-responders. Make the most of precious clinical samples with a wealth of data from every cell.
On-demand webinars

Single cell multi-omics to profile the immune system

Watch this featured webinar to see how single cell sequencing and immune profiling are powerful approaches to improve cancer outcomes in patients.

Integrating single cell genomics into clinical studies

Watch this webinar by AstraZeneca’s Translational Medicine Lead Asaf Rotem, PhD, to discover the many applications of single cell technologies to clinical studies—including monitoring drug effects and tracing rare cells in clinical samples. Dr. Rotem also provides expert guidance on study design and sample compatibility.

Expanding opportunities for single cell RNA-sequencing

In this webinar, learn how single cell methods can enable a deeper understanding of cancer, and explore the benefits of expanding sample compatibility for single cell RNA-seq to PFA-fixed tissues. Plus, hear how Azenta, a 10x Genomics certified CRO, provides expertise across the single cell sequencing workflow to pharmaceutical and biotech clients.

Explore resources to streamline your entire workflow

Publications

Comprehensive insights to power drug discovery

Single cell and spatial tools from 10x Genomics deliver powerful, multiomic insights from complex disease samples that enable you to confidently fuel your drug discovery pipeline with the most promising candidates. See how these tools are helping fundamentally alter our understanding of disease mechanisms, thus accelerating the discovery and development of novel therapeutics.
View more publications

A multi-omic single cell sequencing approach to develop a CD8 T cell specific gene signature for anti-PD1 response in solid tumors

A multi-omic single cell sequencing approach to develop a CD8 T cell specific gene signature for anti-PD1 response in solid tumors

Kumar N, et al. IJC (2022).

Kumar N, et al. IJC (2022).

Single cell T cell landscape and T cell receptor repertoire profiling of AML in context of PD-1 blockade therapy

Single cell T cell landscape and T cell receptor repertoire profiling of AML in context of PD-1 blockade therapy

Abbas HA, et al. Nature Communications (2021).

Abbas HA, et al. Nature Communications (2021).

An N-Cadherin 2 expressing epithelial cell subpopulation predicts response to surgery, chemotherapy and immunotherapy in bladder cancer

An N-Cadherin 2 expressing epithelial cell subpopulation predicts response to surgery, chemotherapy and immunotherapy in bladder cancer

Gouin KH, et al. Nature Communications (2021).

Gouin KH, et al. Nature Communications (2021).

Platforms for drug discovery

Accelerate your drug development with single cell and spatial solutions from 10x Genomics