This year’s Global Virtual Cancer Symposium let us learn about some of the latest discoveries in cancer biology, with leading cancer researchers sharing their work to better understand cancer progression and therapeutic response and resistance. Take a look at their exciting research, and get started on your own with our new sample prep guide for single cell applications in oncology.
10x Genomics Blog
Ready to make a good thing better? Cell Ranger ATAC and ARC software have just received some major improvements! Update to Cell Ranger ATAC v2 and Cell Ranger ARC v2 to see how these powerful tools for computational analysis of single cell open chromatin and transcriptional data have gotten even better.
At 10x Genomics, we strive to make life science research accessible to all. We include complete analysis and visualization software with every assay, and we have shipped hundreds of software releases across our product lines. To take this commitment one step further, we’re excited to release Cloud Analysis, which allows researchers to run a set of our analysis pipelines on the 10x Genomics Cloud for each uploaded 10x dataset at no additional cost.1
Recent technological breakthroughs have led to larger and more complex single cell datasets, with options for increasing cell counts and the ability to collect more information from each cell than previously thought possible. We are moving towards a world where 1 million cell experiments are not only possible, but routine. Regardless of the scale of your experiments, Cloud Analysis ensures that you can quickly analyze your data without spending time and resources on infrastructure.
Scientists from the University of California, San Francisco are shedding light on the molecular mechanisms involved in fear-memory formation, one of our more mysterious cognitive functions. They identified IL-33 as a signaling molecule from hippocampal neurons that triggers a microglia-mediated cleanup process of the synaptic spaces between neurons, an essential function to ensure synaptic plasticity and consolidation of fear memories. Read this blog to learn how single cell sequencing played a part in revealing these new insights into what makes a memory.
To honor Lupus Awareness Month in May, we feature a research publication that makes use of 10x Genomics Single Cell Gene Expression to study the shared baseline gene expression signatures between vaccine response and the flares that occur with one type of lupus (1). Uncovering the cellular activity that contributes to these flares by comparing the underlying immune response to similar activity after vaccination could point to biomarkers of disease and new therapeutic targets.
Our first-ever Next Generation Multiomics Symposium was filled with engaging presentations, covering everything from oncology to immunology, but there was one overarching theme: multiomics enables researchers to reach deeper insights and obtain a more complete picture of complex biology.
An enzyme responsible for deconstructing extracellular matrix proteins in remodeling lung tissue has been identified as a driver of influenza infection severity. Explore the unexpected role of ADAMTS4, how it changes T-cell behavior in infected tissue, suggests novel implications for treating respiratory viral infection, and more, in this blog. Plus, review the full study with our on-demand webinar from primary investigator, Dr. Paul Thomas of St. Jude Children’s Research Hospital.
While scientists have made strides in learning about the pathogenesis of COVID-19, they are still unclear as to precisely what molecular and other factors contribute to the severity of infection. One key piece to solving this puzzle is the peripheral blood. Previous studies show a complex network of immune response in the peripheral blood after infection by SARS-CoV-2, which can be mined for clues. To better understand this complicated, but coordinated, immune response—especially as it pertains to mild versus severe disease—scientists are turning to the increased resolution of single cell analyses.
Though FFPE processing has revolutionized life science research, it damages RNA molecules, complicating transcriptomic-level investigations. Imagine bringing the comprehensive insights of spatially resolved transcriptomics to biobanked samples. Read this blog post to learn about the power of our newest offering, Visium Spatial Gene Expression for FFPE.
10x Genomics Chromium Connect, an automated platform for single cell gene expression and single cell immune profiling, can increase your laboratory’s efficiency and productivity by shortening hands-on time from more than eight hours to less than one hour. In this post, we feature two pharmaceutical companies, Roche Innovation Center Zurich (RICZ) and Pfizer, that are implementing Chromium Connect automation to advance novel targets through their drug pipelines.