Our first-ever Next Generation Multiomics Symposium was filled with engaging presentations, covering everything from oncology to immunology, but there was one overarching theme: multiomics enables researchers to reach deeper insights and obtain a more complete picture of complex biology.
10x Genomics Blog
An enzyme responsible for deconstructing extracellular matrix proteins in remodeling lung tissue has been identified as a driver of influenza infection severity. Explore the unexpected role of ADAMTS4, how it changes T-cell behavior in infected tissue, suggests novel implications for treating respiratory viral infection, and more, in this blog. Plus, review the full study with our on-demand webinar from primary investigator, Dr. Paul Thomas of St. Jude Children’s Research Hospital.
While scientists have made strides in learning about the pathogenesis of COVID-19, they are still unclear as to precisely what molecular and other factors contribute to the severity of infection. One key piece to solving this puzzle is the peripheral blood. Previous studies show a complex network of immune response in the peripheral blood after infection by SARS-CoV-2, which can be mined for clues. To better understand this complicated, but coordinated, immune response—especially as it pertains to mild versus severe disease—scientists are turning to the increased resolution of single cell analyses.
Though FFPE processing has revolutionized life science research, it damages RNA molecules, complicating transcriptomic-level investigations. Imagine bringing the comprehensive insights of spatially resolved transcriptomics to biobanked samples. Read this blog post to learn about the power of our newest offering, Visium Spatial Gene Expression for FFPE.
10x Genomics Chromium Connect, an automated platform for single cell gene expression and single cell immune profiling, can increase your laboratory’s efficiency and productivity by shortening hands-on time from more than eight hours to less than one hour. In this post, we feature two pharmaceutical companies, Roche Innovation Center Zurich (RICZ) and Pfizer, that are implementing Chromium Connect automation to advance novel targets through their drug pipelines.
At our recent Global Psychiatric Disorders Virtual Symposium, we heard from leading neuroscientists using cutting-edge single cell and spatial technologies to build a deeper understanding of the cellular and molecular mechanisms underlying psychiatric disorders.
Explore the latest discoveries in cancer biology at our upcoming Global Virtual Cancer Symposium and find valuable resources for your own research. Download our new guide for getting started with single cell applications to see how each step in your experimental workflow plays a part in generating high-quality data and discovering novel biological insights.
Neuroscience research, especially in areas like neurodegenerative disease, psychiatric disorders, and neural development and differentiation, has been hampered by the inability to build complete pictures and detailed views of complex single cell biology. With multi-assay experiments, researchers can combine technologies to examine the central nervous system from many angles, opening up new and previously inaccessible opportunities for future study.
To support neuroscientists taking a multipronged approach, in February, we launched the Neuroscience Scientific Challenge, giving researchers the chance to win a complete multi-assay experiment, including reagents, sequencing, and service, performed by 10x Genomics partner lab, Applied Genomics, Computation & Translational Core (AGCT). We asked researchers from around the globe to submit their proposals for an experiment using a combination of 10x Genomics single cell and spatial technologies, and the response was incredible. We were thrilled to see how many of you are out there working to deepen our understanding of neuroscience with multidimensional views of the brain and nervous system.
Researchers from 39 institutes and hospitals across China have come together to deeply profile the immune response to SARS-CoV-2 infection. A testament to the potential of scientific collaboration in enabling large-cohort studies, they collectively performed single cell RNA-sequencing on 284 samples from 196 COVID-19 patients and controls, totaling 1.46 million cells.
Explore their findings regarding the influence of population demographics on the immune landscape, surprising evidence of immune cell susceptibility to SARS-CoV-2 infection, and new cellular culprits of the cytokine storm. Plus, find out how 10x Genomics scientists played a part in enabling the success of this team effort, from connecting labs in the midst of a global pandemic to providing guidance and reagents.
April is Irritable Bowel Syndrome (IBS) Awareness Month, and chances are you know someone who struggles with this common disorder. Though it’s estimated that 10–15% of the population has IBS—or between 25 and 45 million people in the United States—it is commonly undiagnosed (1). Worse, the exact cause of IBS remains unknown, and while treatments do exist, they may not completely address symptoms.
Inflammatory bowel disease (IBD), which is diagnosed by the presence of inflammation in the gut, is an umbrella term that encompasses Crohn’s disease, ulcerative colitis, and other syndromes, like IBS. Because IBD and IBS are believed to involve the gut–brain axis, and this enteric nervous system has not yet been well characterized, single cell tools will help enable a deeper understanding of both the heterogeneity of this “second brain” and its complexity, or, how these cells interact with surrounding endothelial, stromal, and immune cells. In this post, we take a look at one research paper that uses single cell sequencing to build an atlas of the human and mouse colon in an effort to understand the disease mechanism behind IBD—and how this knowledge might inform the development of improved therapies.