10x Genomics Blog

  • Exploring cancer progression and therapeutic outcomes with multiomics: Discussions from the 2021 Global Virtual Cancer Symposium

    Andreah Wallace on June 17, 2021

    This year’s Global Virtual Cancer Symposium let us learn about some of the latest discoveries in cancer biology, with leading cancer researchers sharing their work to better understand cancer progression and therapeutic response and resistance. Take a look at their exciting research, and get started on your own with our new sample prep guide for single cell applications in oncology.

    Skin cancer cells—squamous cell carcinoma. This image shows the uncontrolled growth of cells in squamous cell carcinoma, the second most common form of skin cancer. CREDIT: Markus Schober and Elaine Fuchs, The Rockefeller University.
    Skin cancer cells—squamous cell carcinoma. This image shows the uncontrolled growth of cells in squamous cell carcinoma, the second most common form of skin cancer. CREDIT: Markus Schober and Elaine Fuchs, The Rockefeller University.
  • Ask the 10x-perts: 4 reasons to upgrade your Cell Ranger ATAC and ARC software

    Liz Lucero on June 14, 2021

    Ready to make a good thing better? Cell Ranger ATAC and ARC software have just received some major improvements! Update to Cell Ranger ATAC v2 and Cell Ranger ARC v2 to see how these powerful tools for computational analysis of single cell open chromatin and transcriptional data have gotten even better. 

    Image representing regions of accessible chromatin in the genome. These sections of the genome work to control how genes are turned off and on. Credit: Darryl Leja, National Human Genome Research Institute, NIH
    Image representing regions of accessible chromatin in the genome. These sections of the genome work to control how genes are turned off and on. Credit: Darryl Leja, National Human Genome Research Institute, NIH
  • 10x Genomics Cloud Analysis: Faster, easier analysis for every 10x Genomics dataset

    Evan Winget on June 10, 2021

    At 10x Genomics, we strive to make life science research accessible to all. We include complete analysis and visualization software with every assay, and we have shipped hundreds of software releases across our product lines. To take this commitment one step further, we’re excited to release Cloud Analysis, which allows researchers to run a set of our analysis pipelines on the 10x Genomics Cloud for each uploaded 10x dataset at no additional cost.1 

    Recent technological breakthroughs have led to larger and more complex single cell datasets, with options for increasing cell counts and the ability to collect more information from each cell than previously thought possible. We are moving towards a world where 1 million cell experiments are not only possible, but routine. Regardless of the scale of your experiments, Cloud Analysis ensures that you can quickly analyze your data without spending time and resources on infrastructure.

  • Making memories: Microglia clear the way for long-term fear memory consolidation

    Olivia Habern on June 8, 2021

    Scientists from the University of California, San Francisco are shedding light on the molecular mechanisms involved in fear-memory formation, one of our more mysterious cognitive functions. They identified IL-33 as a signaling molecule from hippocampal neurons that triggers a microglia-mediated cleanup process of the synaptic spaces between neurons, an essential function to ensure synaptic plasticity and consolidation of fear memories. Read this blog to learn how single cell sequencing played a part in revealing these new insights into what makes a memory. 

    Neurons. Credit: Leterrier, NeuroCyto Lab, INP, Marseille, France
    Neurons. Credit: Leterrier, NeuroCyto Lab, INP, Marseille, France
  • Predicting disease flares in systemic lupus erythematosus using single cell transcriptomic analysis

    Jeanene Swanson on May 21, 2021

    To honor Lupus Awareness Month in May, we feature a research publication that makes use of 10x Genomics Single Cell Gene Expression to study the shared baseline gene expression signatures between vaccine response and the flares that occur with one type of lupus (1). Uncovering the cellular activity that contributes to these flares by comparing the underlying immune response to similar activity after vaccination could point to biomarkers of disease and new therapeutic targets.

    May is Lupus Awareness Month, which strives to create visibility and advance research. Credit: Lupus Foundation of America.
    May is Lupus Awareness Month, which strives to create visibility and advance research. Credit: Lupus Foundation of America.
  • One protein tips the scales of tolerance and resistance in the immune response to influenza infection

    Olivia Habern on May 12, 2021

    An enzyme responsible for deconstructing extracellular matrix proteins in remodeling lung tissue has been identified as a driver of influenza infection severity. Explore the unexpected role of ADAMTS4, how it changes T-cell behavior in infected tissue, suggests novel implications for treating respiratory viral infection, and more, in this blog. Plus, review the full study with our on-demand webinar from primary investigator, Dr. Paul Thomas of St. Jude Children’s Research Hospital.

    Crystal structure of ADAMTS4. Rendered from PDB 2RJP. CREDIT: Mattyjenjen
    Crystal structure of ADAMTS4. Rendered from PDB 2RJP. CREDIT: Mattyjenjen
  • All in one: Deciphering the COVID-19 immune response at the single cell level with Multiomic Cytometry

    Jeanene Swanson on May 11, 2021
    Scientists continue to investigate how SARS-CoV-2 infection affects immune cells circulating in the peripheral blood. Here, a viral cell is surrounded by blood cells.
    Scientists continue to investigate how SARS-CoV-2 infection affects immune cells circulating in the peripheral blood. Here, a viral cell is surrounded by blood cells.

    While scientists have made strides in learning about the pathogenesis of COVID-19, they are still unclear as to precisely what molecular and other factors contribute to the severity of infection. One key piece to solving this puzzle is the peripheral blood. Previous studies show a complex network of immune response in the peripheral blood after infection by SARS-CoV-2, which can be mined for clues. To better understand this complicated, but coordinated, immune response—especially as it pertains to mild versus severe disease—scientists are turning to the increased resolution of single cell analyses.

  • When spatial gene expression meets FFPE tissue blocks: A modern-day love story

    Leidamarie Tirado-Lee on May 5, 2021

    Though FFPE processing has revolutionized life science research, it damages RNA molecules, complicating transcriptomic-level investigations. Imagine bringing the comprehensive insights of spatially resolved transcriptomics to biobanked samples. Read this blog post to learn about the power of our newest offering, Visium Spatial Gene Expression for FFPE.

    Figure 1. Histopathology slides and FFPE tissue blocks. Credit: MaXPdia, Getty Images.
    Figure 1. Histopathology slides and FFPE tissue blocks. Credit: MaXPdia, Getty Images.
  • Automating single cell workflows: Learn how Roche and Pfizer are using Chromium Connect to optimize drug development

    Jeanene Swanson on May 3, 2021

    10x Genomics Chromium Connect, an automated platform for single cell gene expression and single cell immune profiling, can increase your laboratory’s efficiency and productivity by shortening hands-on time from more than eight hours to less than one hour. In this post, we feature two pharmaceutical companies, Roche Innovation Center Zurich (RICZ) and Pfizer, that are implementing Chromium Connect automation to advance novel targets through their drug pipelines.