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August 2020

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Webinar

August 10 @ 9:00 am - 10:00 am PDT

Using single cell proteogenomics to improve therapies: from cancer to infectious disease

In this webinar, we will tell two stories of how we are using our Enhanced Single Cell Analysis with Protein Expression (ESCAPE™) RNA sequencing assay and MapCell AI™ with the 10x Genomics single cell analysis platform to tackle a diversity of problems in both cancer and infectious disease.

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Webinar

August 11 @ 9:00 am - 10:00 am PDT

A single cell RNA analytical platform for characterizing cell states in gene therapy drug products

Human hematopoietic/stem progenitor (HSPC) CD34+ cells are the core components of ex vivo gene therapy (GT) for the treatment of rare monogenic diseases. Assessment of CD34+ cells for their long-term hematopoietic stem cell (HSC) content before and after ex vivo transduction, as well as in vivo after transplantation, is a critical parameter to establish the efficacy of GT. To overcome the limitations of standard immunophenotyping, we leveraged the high resolution offered by single cell (sc)-RNA-sequencing to capture the heterogeneity of…

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Webinar

August 11 @ 10:00 am - 11:00 am SGT

Using single cell proteogenomics to improve therapies: from cancer to infectious disease

In this webinar, we will tell two stories of how we are using our Enhanced Single Cell Analysis with Protein Expression (ESCAPE™) RNA sequencing assay and MapCell AI™ with the 10x Genomics single cell analysis platform to tackle a diversity of problems in both cancer and infectious disease.

Learn More
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Webinar

August 13 @ 10:00 am - 11:00 am PDT

Single-Cell and Spatial Transcriptomic Profiling of the Septic Kidney

This webinar will discuss a study that combined single-cell gene expression and spatial gene expression to understand the evolution of sepsis in the kidney at the cellular and molecular level. Understanding the pathophysiology of acute kidney injury is crucial for the comprehensive treatment of sepsis and its complications, but the exact cellular and molecular contributors to this multifaceted response remain unknown. Furthermore, the kidney is a highly complex organ, in which epithelial, endothelial, immune, and stromal cells are at constant…

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Webinar

August 19 @ 9:00 am - 10:00 am PDT

Single cell CRISPR screening for mechanistic insights into cell pathways and processes

Without the limitations of a bulk CRISPR screen, what are the possibilities? With a high-resolution view of the transcriptome effects of CRISPR perturbations and increased speed to target, single cell CRISPR screening enables truly scalable functional genomics. Join the 10x Genomics Innovation Lab panel discussion and explore how recent advances in single cell methodology provide deeper insights into cellular response, pathways, and systems as compared to output from bulk screening.

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Webinar

August 27 @ 8:00 am - 9:00 am PDT

Unlocking the Drivers of Neuroinflammation in Neurodegenerative Disease

In this GEN webinar, Dr. Katerina Akassoglou of the Gladstone Institutes will address the gaps in our understanding and treatment of neuroinflammation. Dr. Akassoglou will also describe how single-cell gene expression paired with small-molecule screening and pathway analysis provides an effective functional transcriptomic and drug discovery pipeline. Additionally, she will tell us how she and her team were able to utilize the Chromium Single Cell Gene Expression system from 10x Genomics to characterize the functional transcriptomic landscape of oxidative stress-inducing…

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Workshop

August 31 - September 4

EMBL: Gene Expression at Spatial Resolution

This course will introduce participants to a new generation of a spatially resolved transcriptomics assay provided by 10x Genomics. The Visium Spatial Gene Expression Solution incorporates unbiased, high-throughput total mRNA analysis for intact tissue sections with morphological context, offering a previously inaccessible view of tissue biology. These two complementary methods to study tissue come together on Visium Spatial Gene Expression slides. Through both theoretical sessions as well as extensive hands-on practical work the participants will learn the entire workflow of…

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September 2020

September 9 @ 9:00 am - 10:00 am PDT

Spatially Resolved Transcriptomics: The Landscape of Tools for Spatial Gene Expression

Recent advances in spatially resolved transcriptomics have greatly expanded the knowledge of complex multicellular biological systems. The importance of spatial context to infer deeper biological meaning is unquestionable, but technological constraints have historically limited broad adoption for various applications. The field has quickly expanded in recent years, and several new technologies have been developed that aim to combine gene expression data with spatial information. The vast array of methodologies displays fundamental differences in their approach to obtain this information and,…

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