10x Library

Publications

Click on the arrow to view publication on PubMed. *Pre-prints are available at BioRxiv.

The bone marrow microenvironment at single-cell resolution

Tikhonova AN et al. Nature. 2019 Apr 10; online. doi: 10.1038/s41586-019-1104-8. PMID: 30971824.
Mapped the transcriptional landscape of mouse bone marrow microenvironment both at homeostasis and under conditions of stress-induced haematopoiesis revealing previously unappreciated levels of cellular heterogeneity and considerable transcriptional remodelling under stress conditions

Memory CD4+ T cells are generated in the human fetal intestine

Li N et al. Nat Immunol. 2019 Jan 21; online. doi: 10.1038/s41590-018-0294-9. PMID: 30664737.
Characterize the CD4+ T cell compartment in the human fetal intestine and found evidence for the generation of memory-like CD4+ T cells in the human fetal intestine that is consistent with exposure to foreign antigens.

Gene expression variability across cells and species shapes innate immunity

Hagai T et al. Nature. 2018 Oct 24; online. doi: 10.1038/s41586-018-0657-2. PMID: 30356220.
Using single cell and bulk RNA sequencing, charted the evolutionary architecture of the innate immune response and found that genes that diverge rapidly between species show higher levels of cell-to-cell expression variability than genes that diverge more slowly.

Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment

Azizi E et al. Cell. 2018 Jun 28; online. doi: 10.1016/j.cell.2018.05.060. PMID: 29961579.
Performed single-cell transcriptional profiling combined with T cell receptor sequencing in 27K T cells and characterized populations with unique combinations of clonotypes.

Generalizable visualization of mega-scale single-cell data

Cho H et al. Res Comput Mol Biol. 2018 Apr;10812:251-253. PMID: 29725668.

Linked-Read sequencing resolves complex structural variants

Garcia S et al. 2017 Dec 8; Pre-print*.

Haplotypes drop by drop

Kitzman JO. Nat Biotechnol. 2016 Mar;34(3):296-8. doi: 10.1038/nbt.3500. PMID: 26963554.
*Pre-prints are available at BioRxiv.

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