Dissociated tumor cells (DTCs) from melanoma tissue (female, age 50-60) were obtained by 10x Genomics from Discovery Life Sciences.
Gene Expression and VDJ libraries were generated as outlined in the Chromium GEM-X Single Cell 5' Reagent Kits v3 User Guide (CG000733) and sequenced on an Illumina NovaSeq 6000 with approximately 70,000 read pairs per cell.
Paired-end, dual indexing:
- 28 cycles Read 1
- 10 cycles i7
- 10 cycles i5
- 90 cycles Read 2
The cellranger multi pipeline in Cell Ranger v8.0.0 was used to analyze libraries.