10x Genomics Support/Single Cell Immune Profiling/Documentation/Library Construction/

Chromium Connect Product Notification

  • CG00516_ChromiumConnectProductNotification_Signed_RevA.pdf

    Product Notification, CG00516


    View and download

General Information

Product upgrade announcement regarding Chromium Connect: Hamilton, a partner supplier of 10x Genomics, is introducing CO-RE II technology to the 10x Genomics Chromium Connect. This upgrade will provide Chromium Connect with an extended hardware lifespan, reduced wear and tear, increased precision tip alignment, simplified serviceability, and a reduced need for preventative maintenance. If you have questions, please contact 10x Genomics Support at [email protected] and include "CO-RE II Upgrade" in the subject line.

Frequently Asked Questions

- If CO-RE II tips are received but the Chromium Connect has original (CO-RE) hardware, can CO-RE II tips still be used? CO-RE II tips are compatible with their original (CO-RE) hardware and no hardware upgrade is necessary as of now.

- If there is a hardware upgrade for CO-RE II, can they still use CO-RE tips? Once the hardware upgrade to CO-RE II occurs, CO-RE I tips can no longer be used. We recommend prioritizing using CO-RE tips before using CO-RE II tips.

- Does the material for the tip change with the CO-RE II transition? The material plastics for the CO-RE II tips remain the same as the legacy (CO-RE) tips.

- Will the software give a message about incorrect barcodes when CO-RE II tips are loaded onto the system? CO-RE I and CO-RE II tips contain the same barcode and will be recognized by the system so long as the user is loading 50 uL and 300 uL filtered tips.

- Can I use CO-RE and CO-RE II tips in the same run? Yes, an instrument with the current (CO-RE) hardware can run with a combination of their CO-RE I tips and CO-RE II tips. Once the instrument has been upgraded to CO-RE II hardware, only CO-RE II tips can be used. We recommend prioritizing using CO-RE tips before using CO-RE II tips.

Document Type
Product Notification

Last Modified
June 9, 2023