Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment

Researchers at Memorial Sloan Kettering Cancer Center (New York, NY, USA) performed large-scale, single cell analysis of immune cells within the breast tumor microenvironment. They developed computational tools to normalize and cluster single cell RNA sequencing data across multiple tumors. This revealed a continuum of activation and differentiation states for tumor-associated T cells and macrophages.