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PBMCs from BALB/c mice - 5’ gene expression

Universal 5' dataset analyzed using Cell Ranger 3.0.0

Number of samples on this datasets page1

5’ gene expression data from Peripheral Blood Mononuclear Cells (PBMCs) pooled from BALB/c mice, purchased from CMLabs (catalog number: 12121912). Cells were ~77.5% viable by trypan blue stain. PBMCs are primary cells with relatively small amounts of RNA (~1pg RNA/cell).

The same cDNA was used to generate TCR (vdj_v1_mm_balbc_pbmc_t) and B cell Ig (vdj_v1_mm_balbc_pbmc_b) specific libraries.

Libraries were prepared following the Single Cell V(D)J Reagent Kits User Guide (CG000086 Rev G).

  • ~17,500 cells loaded
  • ~8,140 expected cells recovered (based on cell viability and capture efficiency)
  • 8,000 cells detected
  • 1,235 median genes per cell and 3,683 median UMI counts per cell detected
  • Sequenced on an Illumina NovaSeq 6000 with NovaSeq software v1.4 and with ~71,000 read pairs per cell
  • 150bp read1 (including 16bp Chromium barcode and 10bp UMI), 150bp read2 (transcript), and 8bp i7 sample barcode read configuration
  • Analysis run with --force-cells=8000 (for explanation of the --force-cells parameter see the Calling Cell Barcodes section of the support page)

This dataset is licensed under the Creative Commons Attribution 4.0 International (CC BY 4.0) license. 10x citation guidelines available here.

Product

Universal 5'

Additional Applications

VDJ

Software

Cell Ranger

Subpipeline

cellranger count

10x Instrument(s)

Chromium Controller

Species

Mouse

Anatomical Entity

Blood

Cells or Nuclei

Cells

Selected Cell Types

PBMCs

Biomaterial Type

Cell Suspension

Cell/Nuclei Count

8,000

Donor Count

1

Date Published

2018-11-19