免疫学
重新定义您对先天免疫
和适应性免疫的理解
不只停留在表面
为了深入了解协调配合的先天性和适应性免疫应答，研究人员需要能够在细胞和分子分辨率下对组织进行特征分析的工具。单细胞测序技术就是这样一种方法，从而识别对病原体免疫应答的分子机制，追踪涉及的细胞类型和状态，并发现用于免疫疗法的新生物标记。
下载全面的《免疫学研究指南》，了解单细胞测序技术如何解决免疫学相关重大问题的更多信息。
下载特色网络研讨会 & 研讨会
由免疫学专家带我们全面了解免疫学
揭示潜在的适应性和先天免疫反应机制，以真正改变人类健康的进程。通过这些免疫学主题的网络研讨会，进一步了解免疫学家和10x Genomics的科学家如何通过现有的单细胞解决方案得到相关的见解和发现。
High-Throughput B Cell Screening for Immune Profiling and Antibody Discovery in HIV
Speaker: Ian Setliff, laboratory of Ivelin Georgiev, Vanderbilt University
Learn how researchers from Vanderbilt University used single cell immune sequencing to identify a new panel of broadly neutralizing antibodies against HIV-infected B cells.
Redefining Immune Cell Phenotyping & Characterization
Speaker: Sarah Taylor, Daniel Riorden, Dagmar Walter
Discover the power of multiomic approaches for phenotyping immune cells as 10x Genomics scientists explain how they used the Chromium Single Cell Immune Profiling Solution to characterize gene expression, T- and B-cell clonotypes and cell surface markers in PBMC samples from a cytomegalovirus (CMV) seropositive and seronegative donor.
A New Way of Exploring Immunity
Speaker: Mike Stubbington, Alvaro Martinez Barrio, Dagmar Walter
Explore the capabilities of single cell immune sequencing solutions to characterize the adaptive immune system as 10x Genomics scientists explain how to uncover gene and cell surface protein expression, TCR-pMHC binding specificity, and paired alpha/beta T-cell receptor (TCR) sequences in 160,914 single CD8+ T cells, including 62,858 antigen binding cells.
免疫学研究摘要
《客户研究摘要》将10x Genomics的客户出版物精简为易于理解的实验摘要，详细介绍了如何进行实验，分析数据并得出结论。我们不断增加的摘要列表展示了免疫学家如何使用10x Genomics产品来了解免疫应答背后的多种细胞和分子机制。
Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment
Azizi et al., Cell 2018
Performed single cell transcriptional and immune profiling of breast carcinoma-resident immune cells, showing a continuum of activation and differentiation states for tumor-associated T cells and macrophages.
Gene Expression Variability Across Cells and Species Shapes Innate Immunity
Hagai et al., Nature 2018
Used single cell and bulk RNA sequencing to chart the evolution of the innate immune response in mammals, identifying genes that were differentially expressed upon immune stimulation.
Single Cell Analysis of Fate-mapped Macrophages Reveals Heterogeneity During Atherosclerosis Progression and Regression
Lin et al., JCI Insight 2019
Used single cell RNA sequencing to characterize the cellular states of macrophages in atherosclerotic plaques, showing a spectrum of macrophage activation states.
特色资源
捕获免疫系统的整体快照
以您希望的方式灵活开展免疫学研究。如今可通过单细胞和多组学方法对免疫应答和免疫细胞进行全面表征，包括同时检测细胞表面蛋白、抗原特异性，以及免疫组库、基因表达和染色质分析。通过将10x Genomics技术整合到现有的流式细胞仪工作流程中，您能够对成千上万个免疫细胞开展复杂的表型分析。
精选文献
进入新层次的表征和分辨率
10x Genomics的解决方案使得免疫学研究人员能够跳出传统的细胞分型方法，更全面地了解先天性和适应性免疫。了解研究人员如何将10x Genomics的技术整合到现有的工作流程中。
High-Throughput Mapping of B Cell Receptor Sequences to Antigen Specificity
Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion
The bone marrow microenvironment at single-cell resolution
