The first single-cell sequencing datasets from the Human Cell Atlas initiative are now available to the research community. Featuring data generated with 10x technology, the new datasets collect information from more than 500,000 cells.
The international Human Cell Atlas project aims to create comprehensive reference maps of all the cell types in the human body as a basis for understanding human health and disease. This massive undertaking is being carried out by a consortium of scientist from around the globe who first met in the fall of 2016, and after a year of careful planning, the first phase of the HCA, a suite of flagship projects in key tissues, systems, and organs, was initiated last fall. Now, teams of scientists from the Broad Institute and the Wellcome Trust Center have released the first HCA datasets consisting of single cell gene expression profiles from over half a million cells.
This first release includes single cell RNA-seq profiles for ~530,000 human immune cells (from adult bone marrow and newborn umbilical cord) and ~200,000 human spleen cells, both of which were generated using the Chromium Single Cell Gene Expression Solution. A third dataset of 6,635 lymph node and tumor cells from a mouse melanoma model, was generated using SMART-Seq2.
Released in advance of publication, the HCA datasets are immediately available to the scientific community. This new data represents an important resource for researchers, who will now have access to a massive amount of information that provides insight into basic biological mechanisms and disease. Ultimately, the HCA data will allow researchers to consult and build on established data, promoting new studies as well as collaborative efforts.
Human Cell Atlas youtube channel: a collection presentations recorded at past HCA meetings