Xenium In Situ

High-performance in situ made fast and easy

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Xenium Analyzer alongside a screenshot of the Xenium Explorer software and reagent kits

Experience world-class subcellular in situ profiling from the single cell leader.

The Xenium In Situ platform enables high-throughput subcellular mapping of 100s of RNA targets, revealing new insights into cellular structure and function. The platform includes a versatile and easy-to-use instrument, sensitive and specific chemistry, and a diverse menu of customizable panels. Visualize data with the intuitive Xenium Explorer or use standard format single cell and new open standard spatial data outputs with community-developed analysis tools.

  • Designed for you

    From customizable biologically relevant panels to a simple-to-use workflow and instrument, Xenium makes in situ profiling work for you.
  • Do more with less

    Fast run times, large imageable areas, and ready to explore data outputs let you make the most of your precious samples in less time.
  • High-quality data

    Thoughtful probe design delivers highly sensitive and specific detection of targets in fresh frozen or FFPE tissues, for data you can trust.
  • Access to expert support

    From tissue prep to data analysis our in-field technical experts are available to enable the success of your experiments.
  • A platform for now and the future

    The Xenium platform is a result of the 10x Genomics innovation engine combined with our expertise in single cell and spatial analysis. The robust platform roadmap will feature enhanced analysis capabilities (up to thousands of targets), detection of additional analyte types, and higher throughput.

    Expertly curated and easily customizable content

    Xenium panels are carefully designed using a data-driven approach combined with expert input. The result is a diverse menu of biologically relevant panels. You also have the flexibility to conveniently customize panels for your specific research. Xenium gives you the scale and flexibility to deeply understand the biology you care about.
    Xenium panels designed using a data-driven approach combined with expert input

    Easy-to-use, high-throughput analyzer

    Xenium Analyzer features an intuitive instrument design and user interface that guides you through set-up. Carry out your high-throughput in situ experiments of fresh frozen or FFPE samples with little hands-on time. On-board analysis capabilities include primary and secondary analysis, including cell segmentation all the way to generation of a cell-feature matrix. This enables direct exploration of the data without more processing off-instrument.
    Xenium Analzer

    Intuitive visualization software

    Xenium Explorer is easy-to-use desktop software that allows interactive exploration of the on-instrument subcellular readout from Xenium Analyzer. It also allows for simplified data QC. Alternatively, you have the flexibility to explore your data using the community-developed analysis tools of your choice; Xenium outputs files in familiar standard single cell and new open standards spatial data formats.
    Xenium Analyzer

    High-performance in situ gene expression mapping

    The Xenium platform has been developed to fit into your existing tissue workflow with assays compatible with both fresh frozen and FFPE tissues. High specificity is achieved by leveraging probe-based hybridization and ligation to the target. Individual probes are bright enough for robust detection. The number of probes is tunable to fit each use case.
    Tissue sample analyzed using the Xenium platform

    Xenium is even more powerful when complemented with the 10x toolkit

    Start your research with unbiased, whole transcriptome measurements from Chromium Single Cell and Visium Spatial solutions to discover interesting biology. Then use Xenium In Situ to refine your understanding of key targets.

  • Chromium

    Perform transcriptomic profiling, with multiomic capabilities, in up to a million single cells. Characterize tissue heterogeneity, discover rare cell types, and dissect molecular mechanisms cell by cell.
    Learn about Chromium
  • Visium

    Assess spatial gene expression of FFPE or fresh frozen tissue sections. Harness whole transcriptome discovery while defining the relationship between cellular function and location.
    Learn about Visium
  • Start your Xenium journey