Immunology

Redefine Your
Understanding of Innate
and Adaptive Immunity

Uncover the Layers
of Immune Cell Complexity

Addressing the intricacies of the immune system leads to actionable insight into infectious disease, autoimmune disorders, immunotherapy development, and cancer. Learn how you can explore immunology with unprecedented breadth, depth, and precision to truly change the course of human health using 10x Genomics technology.

 

Beyond the Surface

Learn more about how to further the study of infectious disease, autoimmunity, and cancer with single cell sequencing tools, multiomics, and beyond. Download our immunology research guide to take your research to the next level and comprehensively characterize innate and adaptive immunity.

Download

10x-pert Workshop: A New Way of Exploring Immunity

How will you explore immunology with unprecedented breadth, depth, and precision to truly change the course of human health? In this workshop, you will hear from 10x Genomics’ scientists about:

  • Generating data at single cell resolution from over 150,000 CD8+ T cells from 4 human donors across a highly multiplexed panel of 44 distinct, specific peptide–MHC (pMHC) multimers
  • Uncovering gene and cell surface protein expression, TCR-pMHC binding specificity, and paired alpha/beta T-cell receptor (TCR) sequences from the same single cell
  • Facilitating a greater understanding of how the adaptive immune system responds to immune insults and contributing to the development of therapeutics
Watch

Jul 10, 2019 | 9am PST

 
May 29, 2019 | 9am PT and May 30, 2019| 10am SGT

10x-pert Workshop: Redefining Immune Cell Phenotyping & Characterization

  • 10x-perts:
  • Sarah Taylor
  • Daniel Riorden
  • Dagmar Walter
Watch
 
Immmunotherapies

Advance immunotherapy development by fully characterizing the immune response. Define the genetic repertoire of immune cells and reveal novel TCR-antigen relationships. Identify clonal expansions, peripheral blood markers and measure T-cell exhaustion.

Autoimmunity

Profile diverse cell states involved in autoimmunity and study disease mechanisms for autoimmune disorders. Understand how TCR specificity influences T-cell function. Elucidate the mechanisms involved in autoimmunity development.

Infectious Disease

Better understand the immune response and pathogenicity of disease to pave the way for therapeutic development. Define the genetic repertoire of immune cells and reveal novel TCR-antigen binding to understand T-cell function.

Tumor Microenvironment

Dissect cellular heterogeneity to understand the complex interactions between tumor cells and tumor infiltrating lymphocytes (TILs). Get new insights into tumor immunology by coupling gene expression data with matched, paired clonotypes.

Capture a Holistic Snapshot of the Immune System

Gain the flexibility to perform immunology research the way you want. Comprehensive characterization of the immune response and immune cells, including simultaneous detection of cell surface proteins, antigen specificity, as well as immune repertoire, gene expression, and chromatin profiling is now possible with single cell and multiomic approaches. Perform complex phenotyping in tens of thousands of immune cells by incorporating 10x Genomics technology into your existing flow cytometry workflow.

See how we recently demonstrated the immense scalability of our Feature Barcoding technology to produce a rich dataset elucidating the mechanisms of TCR-pMHC interactions.

Learn about how to perform multiomic phenotyping in single T cells, including cell surface protein and antigen specificity characterization.

Get more in-depth information about how to identify cell-to-cell variation in regulatory elements to better characterize immune cell types.

 

Watch this presentation from AGBT 2019 to see how multiomic approaches can be leveraged to gain a deeper understanding of adaptive immunity.

Getting to the Next Level of Characterization & Resolution

Solutions from 10x Genomics enable immunology researchers to go beyond traditional cellular phenotyping approaches to get a more complete view of innate and adaptive immunity. See how researchers are incorporating 10x Genomics technology into their current workflows.

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Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment
Azizi E et al. Cell. 2018
Performed single-cell transcriptional profiling combined with T cell receptor sequencing in 27K T cells and characterized populations with unique combinations of clonotypes.
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Gene expression variability across cells and species shapes innate immunity
Hagai T et al. Nature. 2018
Using single cell and bulk RNA sequencing, charted the evolutionary architecture of the innate immune response and found that genes that diverge rapidly between species show higher levels of cell-to-cell expression variability than genes that diverge more slowly.
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Memory CD4+ T cells are generated in the human fetal intestine
Li N et al. Nat Immunol. 2019
Characterize the CD4+ T cell compartment in the human fetal intestine and found evidence for the generation of memory-like CD4+ T cells in the human fetal intestine that is consistent with exposure to foreign antigens.
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The bone marrow microenvironment at single-cell resolution
Tikhonova AN et al. Nature. 2019
Mapped the transcriptional landscape of mouse bone marrow microenvironment both at homeostasis and under conditions of stress-induced haematopoiesis revealing previously unappreciated levels of cellular heterogeneity and considerable transcriptional remodelling under stress conditions

Learn More About Our Solutions to Explore the Immune System With Unprecedented Depth, Breadth, and Precision

The Chromium Single Cell Immune Profiling Solution allows you to simultaneously examine the cellular context of the adaptive immune response and immune repertoires of hundreds to tens of thousands of T and B cells in human or mouse on a cell-by-cell basis.

Go to solution

The Chromium Single Cell ATAC Solution allows you to discover cellular heterogeneity stemming from epigenetic variability and better understand the regulation of genes to better define cell state and types for lineage tracing and biomarker discovery.

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The Chromium Single Cell Gene Expression Solution provides an unparalleled approach to uncover cell-to-cell gene expression variability and identify rare cell types from complex biological samples.

Go to solution

Redefine Your Understanding
of Innate and Adaptive Immunity
with Solutions from 10x Genomics

We’re here to help.

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