Understanding of Innate
and Adaptive Immunity
Uncover the Layers
of Immune Cell Complexity
Addressing the intricacies of the immune system leads to actionable insight into infectious disease, autoimmune disorders, immunotherapy development, and cancer. Learn how you can explore immunology with unprecedented breadth, depth, and precision to truly change the course of human health using 10x Genomics technology.
Immunology Research Guide
To develop an extensive understanding of the orchestrated innate and adaptive immune response, researchers need tools that can profile tissues at cellular and molecular resolution. Single cell sequencing technologies can be used in exactly this way — to identify the molecular mechanisms of the immune response to pathogens, trace the cell types and states involved, and uncover novel biomarkers for immunotherapy.
Download our comprehensive Immunology Research Guide and learn more about applying single cell sequencing to address the biggest topics in immunology.Download
Featured Webinars & Seminars
Immunology Experts Take Us Towards a Complete
Understanding of Immunity
Uncover the mechanisms underlying the adaptive and innate immune response, to truly change the course of human health. Learn from fellow immunologists and 10x Genomics scientists about the insights and discoveries now possible with the aid of single cell solutions in these immunology-focused webinars and seminars.
High-Throughput B Cell Screening for Immune Profiling and Antibody Discovery in HIV
Speaker: Ian Setliff, laboratory of Ivelin Georgiev, Vanderbilt University
Learn how researchers from Vanderbilt University used single cell immune sequencing to identify a new panel of broadly neutralizing antibodies against HIV-infected B cells.
Constructing the Human Immune Census
Speaker: Jimmie Ye, UCSF
Listen to UCSF Assistant Professor Jimmie Ye describe his team’s efforts to build a molecular survey of gene expression in one million immune cells from 200 different blood samples, including samples from patients with lupus.
Redefining Immune Cell Phenotyping & Characterization
Speaker: Sarah Taylor, Daniel Riorden, Dagmar Walter
Discover the power of multiomic approaches for phenotyping immune cells as 10x Genomics scientists explain how they used the Chromium Single Cell Immune Profiling Solution to characterize gene expression, T- and B-cell clonotypes and cell surface markers in PBMC samples from a cytomegalovirus (CMV) seropositive and seronegative donor.
A New Way of Exploring Immunity
Speaker: Mike Stubbington, Alvaro Martinez Barrio, Dagmar Walter
Explore the capabilities of single cell immune sequencing solutions to characterize the adaptive immune system as 10x Genomics scientists explain how to uncover gene and cell surface protein expression, TCR-pMHC binding specificity, and paired alpha/beta T-cell receptor (TCR) sequences in 160,914 single CD8+ T cells, including 62,858 antigen binding cells.
Immunology Research Snapshots
The Customer Research Snapshot condenses 10x Genomics customer publications into easy-to-understand experimental summaries, detailing how they performed their experiments, analyzed their data and reached their conclusions. Take a look at our growing list of snapshots, showcasing how immunologists are using 10x Genomics products to understand the diverse cellular and molecular mechanisms underlying the immune response.
Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment
Azizi et al., Cell 2018
Performed single cell transcriptional and immune profiling of breast carcinoma-resident immune cells, showing a continuum of activation and differentiation states for tumor-associated T cells and macrophages.
Gene Expression Variability Across Cells and Species Shapes Innate Immunity
Hagai et al., Nature 2018
Used single cell and bulk RNA sequencing to chart the evolution of the innate immune response in mammals, identifying genes that were differentially expressed upon immune stimulation.
Single Cell Analysis of Fate-mapped Macrophages Reveals Heterogeneity During Atherosclerosis Progression and Regression
Lin et al., JCI Insight 2019
Used single cell RNA sequencing to characterize the cellular states of macrophages in atherosclerotic plaques, showing a spectrum of macrophage activation states.
Capture a Holistic Snapshot of the Immune System
Perform complex phenotyping in tens of thousands of immune cells by incorporating 10x Genomics technology into your existing flow cytometry workflow. See how we did it with these helpful resources.
See how we recently demonstrated the immense scalability of our Feature Barcoding technology to produce a rich dataset elucidating the mechanisms of TCR-pMHC interactions.
Getting to the Next Level of Characterization & Resolution
See how Immunology researchers are incorporating 10x Genomics technology into their current workflows and taking their research to the next level.
Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion
Learn More About Our Products to Explore the Immune System With Unprecedented Depth, Breadth, and Precision
The Chromium Single Cell Immune Profiling Solution allows you to simultaneously examine the cellular context of the adaptive immune response and immune repertoires of hundreds to tens of thousands of T and B cells in human or mouse on a cell-by-cell basis.Learn More
The Chromium Single Cell ATAC Solution allows you to discover cellular heterogeneity stemming from epigenetic variability and better understand the regulation of genes to better define cell state and types for lineage tracing and biomarker discovery.Learn More
The Chromium Single Cell Gene Expression Solution provides an unparalleled approach to uncover cell-to-cell gene expression variability and identify rare cell types from complex biological samples.Learn More
The Visium Spatial Gene Expression solution is a next-generation molecular imaging technology that allows you to classify tissue globally based on the total mRNA, or focus on any region of interest to discover novel gene expression profiles.Learn More