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Introducing a new era of spatial discovery with Visium HD Spatial Gene Expression
- Whole transcriptome analysis at single cell-scale resolution
- Continuous tissue coverage
- Best-in-class data powered by innovative probe-based chemistry and a Visium CytAssist-enabled workflow
Discover the spatial organization of gene expression
The Visium platform enables unbiased molecular profiling of frozen and fixed tissue sections, simple tissue handling, sensitive gene detection, and user-friendly software for visualizing gene expression.
How Visium empowers your research
- Profile whole sections across Capture Areas of up to 11 x 11 mm
Perform discovery and validation studies across entire tissue sections, no need to pre-select regions of interest.
- Analyze RNA, protein, and histology, all in one
Go beyond gene expression. Analyze cellular relationships by combining transcriptomics with histology and protein expression.
- Map fresh frozen, PFA-fixed frozen, FFPE, and tissue microarrays
Access diverse samples with optimized workflows, with proven compatibility on a diverse set of organs across species.
Flexible assays that suit your needs
Assay | HD Spatial Gene Expression | Spatial Gene Expression | Spatial Gene + Protein Expression |
|---|---|---|---|
What you can do | Proven whole transcriptome spatial analysis at single cell-scale resolution and continuous tissue coverage.
| Simultaneous analysis of molecular and imaging data from FFPE & frozen tissue sections.
| Simultaneous analysis of RNA and protein expression of FFPE tissues, using probe-based chemistry and tagged antibodies.
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Species compatibility | Human and mouse | Various | Human and mouse |
Tissue compatibility | FFPE | FFPE, Fresh Frozen, Fixed Frozen | FFPE |
Analyte capture method |
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Simple sample handling and powerful spatial insights
- Start with typical histology workflow on standard glass slides
- Use the instrument to transfer slides to Visium capture areas
- Proceed with the remaining Visium workflow
An intuitive visual canvas for your spatial analysis
Transform sequencing data into gene expression-aligned images
Map the whole transcriptome across your tissue sections with Space Ranger, a set of analysis pipelines that process sequencing data with brightfield and fluorescence microscope images.
Dive into your data and uncover new spatial biology insights
Explore your Space Ranger results using Loupe Browser. Loupe Browser is a desktop application that enables you to easily navigate through molecular expression patterns overlaid on your original tissue section image.
Explore the power of spatial biology
Visium tumor data atlas
Access Visium datasets of FFPE tumor samples and experience the power of spatially resolved biology.
Spatial datasets
Access free, publicly available data from a number of different sample types generated with Visium spatial solutions.
Spatial publications
Browse peer-reviewed publications and explore how researchers use 10x Genomics products to accelerate novel discoveries.
Enhance your spatial discovery with complementary platforms
Expand your Visium insights by interrogating single cell profiling with newly discovered mapped cell types or deepen your understanding of specific targets using Xenium subcellular precision.
Perform transcriptomic profiling, with multiomic capabilities, in up to a million single cells
Characterize tissue heterogeneity, discover rare cell types, and dissect molecular mechanisms cell by cell.
Target 100’s to 1000’s of RNAs in individual cells across a tissue sample
Map gene expression at subcellular resolution with a diverse menu of validated, biologically relevant panels