Dissecting mechanisms of immune tolerance with single cell multiomic analysis

Dissecting mechanisms of immune tolerance with single cell multiomic analysis

Researchers at the Geisel School of Medicine at Dartmouth (Lebanon, NH, USA) provide evidence that V-type immunoglobulin domain-containing suppressor of T-cell activation (VISTA) serves as the earliest checkpoint regulator of T-cell tolerance. VISTA promotes T-cell quiescence and balances cell types and states within the naïve CD4+ T-cell compartment. By examining changes in transcriptome, T-cell repertoire, and open chromatin, the Chromium Single Cell Immune Profiling and Chromium Single Cell ATAC solutions helped reveal the role of VISTA in immune tolerance.

Researchers at the Geisel School of Medicine at Dartmouth (Lebanon, NH, USA) provide evidence that V-type immunoglobulin domain-containing suppressor of T-cell activation (VISTA) serves as the earliest checkpoint regulator of T-cell tolerance. VISTA promotes T-cell quiescence and balances cell types and states within the naïve CD4+ T-cell compartment. By examining changes in transcriptome, T-cell repertoire, and open chromatin, the Chromium Single Cell Immune Profiling and Chromium Single Cell ATAC solutions helped reveal the role of VISTA in immune tolerance.