Neuroscience Research

Reimagine neuroscience with single cell and spatial multiomics

Journey deeper into the brain

Gain a richer understanding of the nervous system and accelerate the discovery of fundamental biology driving complicated, multifactorial neurodegenerative, psychiatric, and neurodevelopmental diseases. Explore 10x Genomics single cell and spatial tools for neuroscience in this short video.

  • Neurodegenerative Disease

    Neurodegenerative Disease

    Build a complete picture of the complex biology of neurodegenerative diseases in multiple dimensions. Advance your understanding of how pathological features affect the surrounding microenvironment and deepen your insights into the cellular contribution to disease pathogenesis and progression.
  • Psychiatric Disorders

    Psychiatric Disorders

    Discover the molecular foundations of psychiatric disorders with single cell and spatial technologies. Characterize disease-associated cellular phenotypes and uncover novel pathological effects. Explore the regulatory landscape of neural cells and identify epigenetic regulators of discrete cell types and states.
  • Developmental Neuroscience

    Developmental Neuroscience

    Achieve a more detailed view of neural development and differentiation than previously possible. Dissect molecular pathways controlling cellular differentiation, identify novel cell subtype markers, and reveal the dynamic gene expression patterns and regulatory landscapes governing cell differentiation.
On-demand webinar

TREM2-Associated Cellular Responses in Alzheimer’s Disease

Watch this featured webinar to see how single cell sequencing can reveal novel functional phenotypes of neural cells in disease. Learn about the effects of the Trem2 AD risk variant on distinct cell types, and hear about previously undescribed roles of glia in AD pathogenesis.

Explore featured resources to enhance your neuroscience research

  • Brochure

    Explore how you can gain a better understanding of the cellular and molecular mechanisms underlying both normal brain function and disease with single cell and spatial gene expression tools.
    Download Brochure
  • Application Note

    Learn how you can characterize large and complex biological tissues, such as the brain, at single cell resolution with Chromium Single Cell Gene Expression.
    Download App Note
  • Poster

    See how you can examine gene expression profiles across different brain regions and in the context of disease by combining histological and transcriptomic analyses with Visium Spatial Gene Expression.
    View Poster
Publications

Neuroscience revealed: from development to health and disease

Gain a holistic understanding of complex biology with technologies from 10x Genomics. See how neuroscientists are using these innovations to gain a multidimensional view of the nervous system.
View all Neuroscience Publications

Single-cell transcriptomic analysis of Alzheimer’s disease

Single-cell transcriptomic analysis of Alzheimer’s disease

Mathys H et al. Nature. 2019

Mathys H et al. Nature. 2019

Spatiotemporal Dynamics of Molecular Pathology in Amyotrophic Lateral Sclerosis

Spatiotemporal Dynamics of Molecular Pathology in Amyotrophic Lateral Sclerosis

Maniatis S et al. Science. 2019

Maniatis S et al. Science. 2019

Single-Cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis

Single-Cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis

Weng Q et al. Cell Stem Cell. 2019

Weng Q et al. Cell Stem Cell. 2019

Products for Neuroscience research

  • Reimagine neuroscience with single cell and spatial solutions from 10x Genomics