Profile cell types and states with 3' gene expression, surface protein expression, and CRISPR perturbations in the same cell.

• Identify and characterize unique brain-region and disease-associated neural cell types to better understand the contributions of cellular states and subtypes to normal brain function and disease pathogenesis.

Spatially profile gene expression with morphological context in intact FFPE or fresh frozen tissue sections.

• Localize molecularly defined cell types in context of brain tissue structures, and simultaneously detect morphology, activity, or connectivity to uncover new insights into brain development and disease.

Profile a defined set of transcripts from single cells or fresh frozen tissue sections to focus on the genes that matter most.

• Use the pre-designed Human Neuroscience Panel containing 1,186 target genes for analysis of neurodegenerative and neuroimmune pathways.

Reveal the epigenomic landscape and analyze chromatin accessibility cell by cell to decipher gene regulatory mechanisms.

• Profile the chromatin accessibility of tens of thousands of single nuclei to gain insight into the regulatory dynamics that underlie normal neural development, aging, and disease.

Explore combined gene expression and chromatin accessibility data from the same cell to uncover gene regulatory programs.

• Deeply characterize immune cell states, uncover gene regulatory programs driving immune cell lineage and differentiation.
• Identify target genes and cell types of genetic variants associated with immune-mediated disease.