One scientist’s single cell journey
What’s the relationship between neuroimmune communication in the gastrointestinal tract and Parkinson’s disease? Dive into this question in this video with Dr. Habibeh Khoshbouei and Phillip Mackie of the McKnight Brain Institute at the University of Florida as they begin their exciting research.
Ready to begin your journey of discovery? Access curated resources to build your own Success Kit and accelerate your scientific discovery.
Neurodegenerative Disease
Build a complete picture of the complex biology of neurodegenerative diseases in multiple dimensions. Advance your understanding of how pathological features affect the surrounding microenvironment and deepen your insights into the cellular contribution to disease pathogenesis and progression.
Psychiatric Disorders
Discover the molecular foundations of psychiatric disorders with single cell and spatial technologies. Characterize disease-associated cellular phenotypes and uncover novel pathological effects. Explore the regulatory landscape of neural cells and identify epigenetic regulators of discrete cell types and states.
Developmental Neuroscience
Achieve a more detailed view of neural development and differentiation than previously possible. Dissect molecular pathways controlling cellular differentiation, identify novel cell subtype markers, and reveal the dynamic gene expression patterns and regulatory landscapes governing cell differentiation.
TREM2-Associated Cellular Responses in Alzheimer’s Disease
Watch this featured webinar to see how single cell sequencing can reveal novel functional phenotypes of neural cells in disease. Learn about the effects of the Trem2 AD risk variant on distinct cell types, and hear about previously undescribed roles of glia in AD pathogenesis.
Explore featured resources to enhance your neuroscience research
Brochure
Explore how you can gain a better understanding of the cellular and molecular mechanisms underlying both normal brain function and disease with single cell and spatial gene expression tools.
Application Note
Learn how you can characterize and spatially profile Alzheimer’s-related neuropathology at single cell resolution with Chromium Single Cell Multiome ATAC + Gene Expression and Visium Spatial Gene Expression for FFPE.
Poster
See how you can examine gene expression profiles across different brain regions and in the context of disease by combining histological and transcriptomic analyses with Visium Spatial Gene Expression.
Neuroscience revealed: from development to health and disease
Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex
Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex
Kristen R Maynard et al. Nature Neuroscience, Feb 2021
Kristen R Maynard et al. Nature Neuroscience, Feb 2021
Single-nucleus chromatin accessibility and transcriptomic characterization in Alzheimer's disease
Single-nucleus chromatin accessibility and transcriptomic characterization in Alzheimer's disease
Samuel Morabito et al. Nature Genetics, Jan 2021
Samuel Morabito et al. Nature Genetics, Jan 2021
Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy
Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy
Sandro Da Mesquita et al. Nature, May 2021
Sandro Da Mesquita et al. Nature, May 2021