Neuroscience Research

Reimagine how you study the brain

One scientist’s single cell journey

What’s the relationship between neuroimmune communication in the gastrointestinal tract and Parkinson’s disease? Dive into this question in this video with Dr. Habibeh Khoshbouei and Phillip Mackie of the McKnight Brain Institute at the University of Florida as they begin their exciting research.

Ready to begin your journey of discovery? Access curated resources to build your own Success Kit and accelerate your scientific discovery.

  • Neurodegenerative Disease

    Neurodegenerative Disease

    Build a complete picture of the complex biology of neurodegenerative diseases in multiple dimensions. Advance your understanding of how pathological features affect the surrounding microenvironment and deepen your insights into the cellular contribution to disease pathogenesis and progression.
  • Psychiatric Disorders

    Psychiatric Disorders

    Discover the molecular foundations of psychiatric disorders with single cell and spatial technologies. Characterize disease-associated cellular phenotypes and uncover novel pathological effects. Explore the regulatory landscape of neural cells and identify epigenetic regulators of discrete cell types and states.
  • Developmental Neuroscience

    Developmental Neuroscience

    Achieve a more detailed view of neural development and differentiation than previously possible. Dissect molecular pathways controlling cellular differentiation, identify novel cell subtype markers, and reveal the dynamic gene expression patterns and regulatory landscapes governing cell differentiation.
On-demand webinar

TREM2-Associated Cellular Responses in Alzheimer’s Disease

Watch this featured webinar to see how single cell sequencing can reveal novel functional phenotypes of neural cells in disease. Learn about the effects of the Trem2 AD risk variant on distinct cell types, and hear about previously undescribed roles of glia in AD pathogenesis.

Explore featured resources to enhance your neuroscience research

  • Brochure

    Explore how you can gain a better understanding of the cellular and molecular mechanisms underlying both normal brain function and disease with single cell and spatial gene expression tools.
    Download Brochure
  • Application Note

    Learn how you can characterize and spatially profile Alzheimer’s-related neuropathology at single cell resolution with Chromium Single Cell Multiome ATAC + Gene Expression and Visium Spatial Gene Expression for FFPE.
  • Poster

    See how you can examine gene expression profiles across different brain regions and in the context of disease by combining histological and transcriptomic analyses with Visium Spatial Gene Expression.
Publications

Neuroscience revealed: from development to health and disease

Gain a holistic understanding of complex biology with technologies from 10x Genomics. See how neuroscientists are using these innovations to gain a multidimensional view of the nervous system.
View all Neuroscience Publications

Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex

Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex

Kristen R Maynard et al. Nature Neuroscience, Feb 2021

Kristen R Maynard et al. Nature Neuroscience, Feb 2021

Single-nucleus chromatin accessibility and transcriptomic characterization in Alzheimer's disease

Single-nucleus chromatin accessibility and transcriptomic characterization in Alzheimer's disease

Samuel Morabito et al. Nature Genetics, Jan 2021

Samuel Morabito et al. Nature Genetics, Jan 2021

Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy

Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy

Sandro Da Mesquita et al. Nature, May 2021

Sandro Da Mesquita et al. Nature, May 2021

Products for Neuroscience research

  • Reimagine neuroscience with single cell and spatial solutions from 10x Genomics