Gain a multidimensional view of cancer
Address the true complexities of cancer with sharper resolution into the cell types and states that drive cancer. 10x Genomics develops technologies that illuminate the details and dynamics of this complicated disease.
Dissect the tumor and immune contexture
See how the combination of single cell gene expression and spatial profiling technologies enables researchers to explore tumor heterogeneity and the complex interactions of the tumor microenvironment (TME).
Tumor Heterogeneity
Build integrated single cell and spatial atlases, unmask intratumoral heterogeneity, and trace transcriptomic and epigenetic modulators of clonal evolution within tumors and across cancer types.
Tumor Microenvironment
Uncover the influence of tissue architecture on cancer progression, immune infiltration, and therapeutic response and identify the epigenetic regulators and transcriptomic programs driving diverse phenotypes and developmental trajectories.
Immuno-oncology
Advance immunotherapies by characterizing immune cell modulation in tumor progression. Define the receptor repertoire of infiltrating and peripheral immune cells mediating anti-tumor responses.
Therapeutic Development
Discover novel therapeutic targets, explore how therapeutics modulate cell populations and states within the tumor microenvironment, and understand resistance mechanisms governed by transcriptomic and epigenetic remodeling.
Explore the power of spatial biology
Access 10x Genomics-generated Visium datasets of formalin-fixed, paraffin-embedded tumor samples and experience the power of spatially resolved biology for yourself.
Visualize Cancer in Multiple Dimensions
Researchers at the Fred Hutchinson Cancer Research Center are using multidimensional single cell analysis to peer deeper into the tumor microenvironment. These technologies are helping them investigate the body’s response to tumors, discover key driver mutations, and inform why treatments fail.
Explore featured resources to enhance your oncology research
Sample Prep Guide
Get the most out of your single cell experiments with this essential guide, filled with best practices and useful resources to help you optimize your sample prep.
Application Note
Learn how Visium for FFPE complemented pathological assessment of tumor microenvironments with spatial gene expression insights for key prostate cancer markers and cell types.
Poster
See how spatial gene expression profiling can provide a powerful complement to traditional histopathology, enabling a detailed view of the tumor microenvironment architecture.
Unraveling cancer complexities
Integrating microarray-based spatial transcriptomics and single-cell RNA-seq reveals tissue architecture in pancreatic ductal adenocarcinomas
Integrating microarray-based spatial transcriptomics and single-cell RNA-seq reveals tissue architecture in pancreatic ductal adenocarcinomas
Nature Biotechnology, Jan 2020
Nature Biotechnology, Jan 2020
Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion
Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion
Nature Biotechnology, Aug 2018
Nature Biotechnology, Aug 2018
Increased intratumoral heterogeneity after the onset of therapy resistance in small-cell lung cancer
Increased intratumoral heterogeneity after the onset of therapy resistance in small-cell lung cancer
Nature Cancer. 2020, C. Allison Stewart, et al.
Nature Cancer. 2020, C. Allison Stewart, et al.