Superior spatial data quality, faster time to results
8 benchmarking studies,
1 standout platform
The Xenium platform consistently delivers
- More transcripts on shared genes
- Better spatial resolution and discrimination of cell types
- Greater specificity and lower background noise
- Higher consistency with orthogonal benchmarking
Source: Ren et al. (2024) courtesy of Dr. Zexian Zeng, Peking University.
Industry-leading speed & throughput
Analyze up to 472 mm² of tissue in 3 days or less for <500-gene panels or 6 days for 5,000-gene panels.
Comparing maximum tissue area per run of 427 mm² vs. 300 mm² for other platforms.
Ultimate versatility, streamlined workflows
The Xenium platform offers the most comprehensive off-the-shelf panels with the most flexible customization capabilities, from add-on to full custom panels, all with a robust, universal workflow.
Unmatched customization
- Easily customize pre-designed panels with up to 100 genes, or design fully custom panels of up to 480 genes, with the Custom Panel Designer
- Go from design to delivered in just 4–6 weeks
- Tailor your order size to fit your experiment and your budget, with sizes as small as 4 reactions
- Take advantage of advanced custom services to add TCR/BCRs, isoforms, SNVs, xenografts, and viral/bacterial sequences onto your panels
The Xenium platform is the only high-plex single cell spatial transcriptomics solution capable of detecting TCR/BCR sequences, isoforms, and SNVs due to its proprietary padlock probe chemistry
See the custom panels in action
Over 10,500 custom genes delivered to customers*
Custom probes identify spatial localization of specific SNVs
Image adapted from Figure 2E of Ding et al. 2024.
100-gene custom panel maps spatial development of maize
Image adapted from Figure 3 of Wu et al. 2025.
Custom viral probes detect Hepatitis B RNA with high sensitivity
Data provided courtesy of Nadina Wand and Jane McKeating, University of Oxford and Kings College Hospital, London.
A universal tissue-agnostic workflow saves time and samples
- One sample prep workflow - Avoid the headaches of optimizing conditions on a per-tissue basis
- One cell segmentation stain mix - Eliminate the need to select stain mixes for each tissue type
- One comprehensive panel menu - Access the industry’s largest menu of off-the-shelf panels with >10 human and mouse options, ranging from 100s to 1,000s of genes
Maximize insights, minimize headaches
Interpretable data ready immediately after a run
Optimized data analysis without the hassle
10x Genomics Xenium software
- Provides free-of-charge analysis and visualization
- Delivers interpretable data as soon as the run is complete
- Outputs unified tissue images, making it easy to pan and zoom through the entire sample image
- Enables easy overlay of H&E and IF images with gene expression data
- Expedites panel customization with an intuitive Custom Panel Designer
Other in situ platform software
- Requires annual license fees after the first year
- Requires data transfer and analysis via the cloud before data can be viewed
- Outputs analysis per field of view (FOV) and requires FOV stitching, which may lead to edge artifacts [1]
- Lacks the ability to register H&E or IF images within the software
- No self-serve custom panel design capabilities
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