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What is Loupe V(D)J Browser?

What is Loupe V(D)J Browser?

Loupe V(D)J Browser is a desktop application for Windows and macOS that allows the user to analyze, search, and visualize V(D)J sequences and clonotypes from 5' Chromium Single Cell Immune Profiling

Loupe is named for a jeweler's loupe, which is used to inspect gems.

Using Loupe V(D)J Browser, you can quickly:

  • Determine the most common paired alpha and beta TCR chains or heavy and light BCR chains in your sample
  • Filter clonotypes based on their antigen specificity or UMI count per antigen
  • Examine full-length V, D, and J amino acid and nucleotide sequences to detect variants within V(D)J transcripts
  • Search for motifs within CDR3 regions
  • Compare clonotype frequencies between samples

To find out how to use Loupe V(D)J Browser to explore your data, start the tutorial.