In Situ Analysis Technology

Zoom in on Your Spatial Data

Visualize and map genes at high sensitivity and subcellular resolution in situ

In Situ analysis allows researchers to enhance and refine spatial transcriptomics data by creating targeted gene expression maps at cellular and subcellular resolution on tissue sections. By finely mapping complex cellular relationships and networks, biological processes leading to disease can be more clearly elucidated. Already, this technology has contributed to new insights into cell atlassing, neurodegenerative disease, immunology, and cancer.

  • Map Cellular Relationships

    Map Cellular Relationships

    Finely map spatial information at the cellular and subcellular level, zooming in on targeted genes of interest.
  • Preserve Tissue Morphology

    Preserve Tissue Morphology

    Simultaneously detect gene and protein expression from fresh-frozen, fixed-frozen, and FFPE tissue, and map the data to an H&E image.
  • Complements Spatial and Single Cell Data

    Complements Spatial and Single Cell Data

    Complement and refine your Visium spatial transcriptomics and/or single cell data to dive deeper with a robust, highly sensitive, and specific in situ end-to-end workflow.

Key Features

  • Optimized chemistry and integrated hardware provide an end-to-end solution with highly resolved spatial outputs that can be analyzed using our software and visualization tools
  • Capable of interrogating RNA targets simultaneously with proteins on the same tissue section with high sensitivity and specificity at subcellular resolution
  • Extremely flexible solution that enables the use of one of our pre-designed panels, with the option to customize
  • Enough throughput to enable high-power biological studies and pre-clinical cohort–based design
Publications

Cellular relationships revealed: From development to health and disease

See how researchers are applying in situ analysis to map cellular relationships and dive deeper into spatial transcriptomic data.