Chromium Controller

Single cell resolution to maximize biological insight

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Chromium Controller instrument

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  • Cell by cell characterization

    Go beyond population averages to capture and resolve cellular heterogeneity.

  • Rapid single cell profiling

    Partition hundreds to tens of thousands of nuclei or cells per chip in minutes.

  • Compact and flexible

    Small instrument footprint easily integrates into existing laboratory infrastructure.

One system, many single cell approaches

  • The Chromium Controller uses advanced microfluidics to perform single cell partitioning and barcoding in a matter of minutes. Powered by Next GEM technology, the Chromium Controller enables integrated analysis of single cells at massive scale.
    Chromium instrument, left-facing angle, with measurements 8" x 8" x 12"
  • Our suite of Chromium Single Cell products can capture molecular readouts of cell activity in multiple dimensions, including gene expression, cell surface proteins, immune clonotype, antigen specificity, and chromatin accessibility. The key to this technology is its ability to generate tens of thousands of single cell partitions, each containing an identifying barcode for downstream analysis.
    Illustration of Next GEM technology showing the single cell barcoding process that takes place within the Chromium instrument
  • Resolve complex biology

    Uncover molecular insights and resolve highly complex biological systems. Capture the full heterogeneity of a sample, in tens of thousands of cells.

    Explore Biology Like Never Before: Chromium Single Cell Solutions

  • Multiomic cellular readout

    Gain more insights from precious samples. Measure mRNA, cell surface proteins, immune clonotype, antigen specificity, CRISPR perturbations, and chromatin accessibility. Uncover molecular insights, dissect cell-type differences, investigate the innate and adaptive immune system, detect novel subtypes and biomarkers, and map the epigenetic landscape, cell by cell.

    Single cell RNA sequencing can help connect datasets for multiple dimensions to reveal a rich picture of cell phenotypes

  • Flexible workflow

    Our suite of Chromium Single Cell products has been validated on fixed, fresh, and frozen samples, as well as whole cells and nuclei. Leverage biological insights with easy-to-use analysis and visualization software.

    Getting Started with Single Cell Gene Expression

Proven Results

Watch how researchers are using Chromium Controller.

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Find the latest app notes and other documentation for Chromium Controller.

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Search peer-reviewed publications using Chromium Controller

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Proven Results

Videos

Watch how researchers are using Chromium Controller.

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Resources

Find the latest app notes and other documentation for Chromium Controller.

Getting Started with Single Cell Gene Expression

Getting Started with Single Cell Gene Expression

Experiment Planning Guide, 10x Genomics

Experiment Planning Guide, 10x Genomics

Tools for Discovering Biology at True Resolution

Tools for Discovering Biology at True Resolution

Product Offerings from 10x Genomics

Product Offerings from 10x Genomics

The Power of Single Cell Partitioning

The Power of Single Cell Partitioning

Chromium Technology Brochure, 10x Genomics

Chromium Technology Brochure, 10x Genomics

Publications

Search peer-reviewed publications using Chromium Controller

Single-Cell Transcriptome and Antigen-Immunoglobin Analysis Reveals the Diversity of B Cells in Non-Small Cell Lung Cancer.

Single-Cell Transcriptome and Antigen-Immunoglobin Analysis Reveals the Diversity of B Cells in Non-Small Cell Lung Cancer.

Genome Biology. 2020, J Chen, et al.

Genome Biology. 2020, J Chen, et al.

COVID-19 Severity Correlates with Airway Epithelium-Immune Cell Interactions Identified by Single-Cell Analysis.

COVID-19 Severity Correlates with Airway Epithelium-Immune Cell Interactions Identified by Single-Cell Analysis.

Nature Biotechnology. 2020, RL Chua, et al.

Nature Biotechnology. 2020, RL Chua, et al.

Human and Mouse Single-Nucleus Transcriptomics Reveal TREM2-Dependent and TREM2-Independent Cellular Responses in Alzheimer’s Disease.

Human and Mouse Single-Nucleus Transcriptomics Reveal TREM2-Dependent and TREM2-Independent Cellular Responses in Alzheimer’s Disease.

Nature Medicine. 2020, Y Zhou, et al.

Nature Medicine. 2020, Y Zhou, et al.

Our End-to-End Solution

Chromium Controller

Our compact instrument

Our automated instrument

Chromium Single Cell Reagents

With our reagent kits, capture and amplify mRNA, profile the immune repertoire, identify CRISPR perturbations, detect chromatin accessibility, and more.

Analysis and Visualization Software

Convert your data to biologically meaningful insights and interactively explore your results with easy-to-use software.

World-Class Technical and Customer Support

Our expert support team can be contacted by phone or email.

Frequently Asked Questions

The Chromium Controller has a small instrument footprint that easily integrates into existing laboratory infrastructure.

  • Weight: 12.5 lb (5.6 kg)

  • Size: (W X D X H) 7.9 x 10.3 x 6.4 in (20 x 26.3 x 16.4 cm)

  • Ventilation Requirement: Minimum 4 in (10 cm) around all sides

  • Electrical Requirements: Nominal 100–240 Vac, 50–60 Hz, 25 W, from a standard 3-prong wall receptacle that includes a safety ground pin

  • Usable Temperature Range: 18–28°C (64–82°F)

  • Humidity: 85% Max (Non-Condensing)

  • Altitude: 0–6,560 ft (0–2,000 m)

For additional information, see the Chromium Controller Specifications manual

Chromium Controller Specifications manual

The Chromium Controller is compatible with our suite of Chromium Single Cell products, including Single Cell Gene Expression, Single Cell Immune Profiling, and Single Cell ATAC. Capture molecular readouts of cell activity in multiple dimensions, including gene expression, cell surface proteins, immune clonotype, antigen specificity, and chromatin accessibility.

Chromium Single Cell products require a number of assay-dependent reagents and consumables. Explore our Product Selector to determine the components necessary for your application. Additional kits, reagents, and laboratory equipment are required. Please see individual kit User Guides, available on our Support website for further details.

You can process between 1–8 samples in one run, loading up to 10,000 cells per sample.

Decontamination should be performed in accordance with institutional guidelines. For general guidance on how to clean the Chromium Controller, please review our Chromium Controller Specifications documentation

Chromium Controller Specifications documentation

Compatible Products

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