Flex, reimagined
Plate-based multiplexing has transformed Flex, enabling unprecedented scale. And because it’s powered by Chromium automated cell partitioning, superior performance comes standard. The benefits of plates plus Flex:
Profile up to 384 samples in a 96-well format
Run partial plates today, save the rest for later
Streamline sample handling with automation compatibility
Why choose Flex?
Game-changing scale
Increase cell and sample throughput dramatically with convenient plate-based multiplexing
Unmatched performance
Detect more genes with less sequencing from fresh, frozen, and fixed samples (even FFPE)
On-demand reagent flexibility
Scale at your pace by running partial plates, using only the reagents you need, when you need them
Deep multiomic profiling
Perform comprehensive analysis with capture of CRISPR guides, cell surface protein, or intracellular protein
The transformational power of plates
The new GEM-X Flex redefines high-sample single cell
Profile up to 384 samples or up to 100 million cells per week with plate-based multiplexing
Reduce waste with the flexibility to run partial plates: use only the reagents you need now, save the rest for later
Minimize handling and accelerate your workflow with 96-well plates and automation compatibility
Ultimate workflow flexibility
Tailor your workflow to meet your research needs. The new Flex has unique capabilities that let you:
Flex the cell number
Profile anywhere up to 100 million cells per week.
Flex the sample type
Access fresh, frozen, and FFPE samples. Fix, batch, and run on your schedule.
Flex the multiomic data
Capture cell surface protein, intracellular protein, and CRISPR guides.
Flex is perfect for...
Profiling clinical samples at scale
Learn how one researcher batched 32 lung cancer samples across three clinical stages, profiling ~900k cells in one run, revealing novel insights into progression of two cancer subtypes.
Easy, reliable processing of blood samples
Get the details on direct fixation and storage of whole blood for downstream scRNA-seq, preserving critical biology and capturing fragile cell types.
Analysis of intracellular signaling pathways
See how a new method for highly sensitive profiling of intracellular protein reveals patient-specific activation of signaling pathways in kidney cancer.
How researchers are using Flex
Bringing single cell for FFPE samples to the field of pathology
Hear from Dr. Philip Bischoff, a resident pathologist and clinical scientist at Charité University Hospital in Berlin, about the advantages of retrospective analysis of clinical FFPE samples.
Evaluating novel combination drug therapies for cancer treatment
Learn how a team at St. Jude Children's Research Hospital explored the mechanism of action for a new multi-drug therapy against leukemia, revealing data that points to increased efficacy of a common chemotherapeutic agent.
Cancer, immunology, neuroscience and more...
Explore our publications library to see how scientists around the world are using the Flex assay to move their research forward across a broad range of applications.
What researchers are saying about Flex
The new 384-plex Flex assay from 10x Genomics is a game changer— enabling the profiling of millions of cells at a fraction of the cost. By fixing cells for batching and ensuring compatibility with liquid-handling automation, we can now explore functional immune responses with unprecedented depth and precision.Peter Skene, PhDSenior Director, High Resolution Immunology at the Allen Institute
How Flex works
Workflow overview
Performance highlights
Automated cell partitioning and probe-based chemistry delivers highest data quality
Reveal more biology by detecting the most genes per cell at low sequencing costs
Get more from every sample with up to 80% cell recovery, low cell inputs, and capture of fragile cells
Partition and barcode millions of cells in just minutes
Ensure high-quality, consistent performance with an R² of 0.97 across runs, users, and timepoints
Featured resources
Product Sheet
View performance benefits, product specs, workflow diagrams, and assay data for GEM-X Flex v2.
Experiment builder
Explore kit options, and configure your single cell study to fit your research needs.
Broad, versatile portfolio of single cell assays
Analyze chromatin accessibility and examine gene regulatory mechanisms with our Epi kits. Work with diverse species, gather broad transcript information (isoforms, SNPS, lncRNA, etc.), or perform V(D)J discovery with our Universal Gene Expression kits.