Chromium Single Cell

Single cell built for your success

Single cell analysis enables meaningful discoveries

Bulk sequencing averages readouts, missing critical details driving complex biology. Single cell sequencing allows scientists to see the unique gene expression patterns of each cell. This view more fully characterizes tissue heterogeneity, revealing the rare cell types that have big consequences in health and disease.

The Chromium Advantage

  • Higher gene sensitivity and up to 80% cell recovery efficiency.

  • Enhanced detection of challenging cell types, including neutrophils.

  • Reduce hands-on time and lower the risk of errors with instrument-supported automation of the most critical workflow steps.

  • Produce higher quality libraries that can be sequenced at lower depths.

  • Backed by 10 years, over 2,200 patents, and >$1.5B in R&D investment.

Innovations developed for your success at every step

Our world-class support team is here to boost your success from sample prep to data analysis.

Access more sample types

Profile fresh, frozen, or fixed samples—even FFPE—with optimized protocols for proven performance

Automate critical steps to reduce error

Produce up to 8M barcoded partitions in just minutes, with up to 80% cell recovery

Construct high-quality sequence-ready libraries

Generate libraries with up to 95% usable reads, letting you detect more genes at lower sequencing costs

Analyze & discover with ease

Process and visualize your data with powerful software tools—no bioinformatics experience required

Performance, reproducibility & cost-efficiency built in

GEM-X innovations plus push-button automation deliver the world's fastest, highest quality cell partitioning & barcoding. Get the most out of your research budget with improved cell recovery and lower sequencing depth requirements.

Broad, flexible portfolio of assays

Be confident that you'll get high-quality data every time, no matter the assay.

Flex

Fix, batch, and run on your schedule.

  • Protein coding gene coverage: Performs well with low-quality and FFPE samples

  • Multiomic readouts from the same cell: Gene expression, Protein, CRISPR

  • Throughput options: Up to 8M cells (1–3,072 samples) per run

Products

Universal

Species agnostic. Maximum versatility.

  • Whole transcriptome coverage: Delivers broadest set of information, including isoforms, SNPs, etc.

  • Multiomic readouts from the same cell: 3' or 5' gene expression, TCR/BCR, Protein, CRISPR

  • Throughput options: Up to 160,000 cells (1–8 samples) per run

Epi Chromatin

Unmask epigenomic profiles.

  • ATAC-seq chemistry: Explore open chromatin regions and link directly to 3' gene expression (Multiome kit)

  • Multiomic readouts from the same cell: Chromatin accessibility, 3' gene expression

  • Throughput options: Up to 80,000 nuclei (1–8 samples) per run

During the past years, we observed many advances in single cell technologies thanks to 10x Genomics. This multi-omics approach is very useful for scientists and for physicians to understand human disorders.
David Michonneau, PhDProfessor of Hematology at Saint-Louis Hospital

Amplify your research gains

Access the greatest application breadth on the market with superior multiomic integration and 40+ demonstrated protocols.

Gene expression

Characterize the unique transcriptomic profiles of each cell in your sample

Immune profiling

Obtain functional data for antibody/TCR discovery

CRISPR screening

Directly link CRISPR guide RNAs to the resulting perturbed phenotypes

Bring the Chromium advantage to your lab

Explore the resources below to learn more about your options and how to get started.

Unlock the full spectrum of biology

Expand your Chromium Single Cell insights by adding spatial context to the whole transcriptome or targeted genes.See how researchers used Chromium, Visium, and Xenium assays to study human lung development
Platform
Chromium Single Cell

Chromium Single Cell

See Chromium products
Visium Spatial

Visium Spatial

Learn about Visium HD
Xenium In Situ

Xenium In Situ

Learn about Xenium
When to use
Comprehensive single cell dataIdeal for deep characterization of cell populations and states.
High-resolution spatial gene expressionUnderstand complex tissues, neighborhoods, and cell to cell interactions. Integration with other spatial-omics, histology, and morphology.
Why to use
Unbiased single cell discovery High per-gene sensitivity
Unbiased spatial discovery
Targeted spatial exploration High per-gene sensitivity
Applications
Whole transcriptome gene expression Protein TCR, BCR CRISPR ATAC
Whole transcriptome gene expression
Targeted gene expression (up to 5,000 genes)
Resolution
Single cell
Transcripts assigned to 2-µm areas
Single cell
Data readout
NGS-based
NGS-based
Imaging-based
Sample compatibility
Single cell or nuclei suspensions from fresh, frozen, or FFPE samples
FFPE Fresh frozen Fixed frozen
Fresh frozen FFPE
Chromium Single Cell

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